Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (4): 119-122.doi: 10.6040/j.issn.1671-7554.0.2021.1104

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A case report of misdiagnosed cerebral amyloid angiopathy-related inflammation and literature review

SONG Luoqing, ZHOU Guoyu, YE Xiang, LU Mei, ZHAO Xinjing   

  1. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-04-22

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Abstract: Objective To analyze the clinical manifestations and imaging features of a patient with misdiagnosed cerebral amyloid angiopathy-related inflammation(CAA-RI)in order to improve clinicians understanding of this disease. Methods The clinical data of a patient with CAA-RI were collected and analyzed, and relevant literature was reviewed. Results The patient was a 66-year-old female, admitted due to episodic loss of consciousness accompanied by convulsions for 9 years. Before admission, the patients memory gradually declined for 4 months. Physical examination showed decrease in recent memory, calculation ability and judgment. Brain imaging showed multiple old bleeding signals and local enhancement in the left cerebral hemisphere, multiple ischemic lesions or inflammatory changes in the left side of brain and stratified necrosis of the left occipital cortex. Mini Mental State Examination score was 14. Conclusion CAA-RI has various clinical manifestations. If a middle-aged or elderly patient has cognition impairment, seizure, headache or other neurologic deficits, imaging examination should be conducted. Especially when MRI shows asymmetric white matter hypersignal with multiple cerebral microbleeds, clinicians should be on alert for CAA-RI.

Key words: Cerebral amyloid angiopathy-related inflammation, Symptomatic epilepsy, Cognitive impairment

CLC Number: 

  • R743.9
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