JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (8): 68-71.doi: 10.6040/j.issn.1671-7554.0.2014.067

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Preliminary study of magnetic resonance intravoxel incoherent motion in the diagnosis of patients with mild cognitive impairment

DONG Dong1,2, WANG Xinyi3   

  1. 1. School of Medcine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250001, Shandong, China;
    2. Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China;
    3. Department of Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2014-02-11 Revised:2014-06-10 Online:2014-08-10 Published:2014-08-10

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Abstract: Objective To investigate the difference of rCBFivim between the aged people who suffered mild cognitive impairment (MCI) and who showed normal cognition, and to evaluate the value of the intravoxel incoherent motion(IVIM) in the diagnosis of MCI. Methods The patients who visited the Neurology Department of Qianfoshan Hospital Affiliated to Shandong University from July 2012 to May 2013 with complaints of memory loss were enrolled in this study. Twenty MCI patients(MCI group) and 20 individuals with normal cognition(NC group) were performed IVIM detection. The values of D* and f were measured in the areas of both sides of frontal, parietal, occipital lobe, temporal lobe and hippocampus, followed by the calculation of rCBFivim. Results Compared with NC group, rCBFivim significantly decreased in the frontal, parietal, temporal lobe and the area of hippocampus in MCI group (all P<0.05). Compared with NC group, rCBFivim of MCI group also decreased in the cerebellum and occipital lobe, which showed no statistical difference(all P>0.05). Conclusion The intravoxel incoherent motion technique is helpful for the diagnosis of MCI, and it is an useful tool for the assessment of cerebral blood flow in patients with MCI.

Key words: Intravoxel incoherent motion, Magnetic resonance perfusion imaging, Mild cognitive impairment

CLC Number: 

  • R574
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