Abstract:

 Objective  To investigate the correlation between hypertriglyceridemic-waist phenotype (HTWC) and mild cognitive impairment (MCI) in patients with impaired glucose tolerance (IGT). Methods  A number of 200 patients with IGT were divided into four groups: normal triglyceride and waist circumference group (group A, n=45),simple abdominal obesity group (group B, n=49),  simple high triglyceride group (group C, n=48),HTWC group (group D, n=58). Indexes such as fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), height, weight, waist circumference, hip circumference, blood pressure, and intimae-media thickness (IMT) were measured. Mini-mental state examination (MMSE) and Montreal cognitive assessment (MOCA) were applied to evaluate cognitive function. Results  The MMSE and MOCA of group D were significantly lower than those of the other three groups (P< 0.01). Group D had higher prevalence of MCI than the other three groups (P<0.01).  Conclusion  Hypertriglyceridemic-waist phenotype is correlated with mild cognitive impairment.

Key words: Impaired glucose tolerance, Mild cognitive impairment, Hypertriglyceridemic-waist phenotype