JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (8): 63-67.doi: 10.6040/j.issn.1671-7554.0.2013.730

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Difference of daily blood glucose profiles in hepatogenous diabetes and type 2 diabetes mellitus

XIAN Yuxin, SUN Ruixia, LI Li, LYU Wenshan, CAO Caixia, ZHANG Jietao, WANG Jing, GAO Yanyan   

  1. Department of Endocrinology and Metabolism, East Campus, The Affiliated Hospital of Qingdao University, Qingdao 266100, Shandong, China
  • Received:2013-12-03 Revised:2014-12-03 Online:2014-08-10 Published:2014-08-10

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Abstract: Objective To study the characteristics of daily blood glucose profiles in hepatogenous diabetes (HD). Methods 20 newly diagnosed hepatogenous diabetes (HD group) and 20 newly diagnosed type 2 diabetes mellitus (DM2 group) patients were measured by continuous glucose monitoring system for 72 hours. Results There was no significant difference in the mean blood glucose in the two groups(P>0.05). In HD group, the levels of fasting plasma glucose and 3:00 blood glucose were significantly lower than those of DM2 group, and the levels of 2 h post-breakfast blood glucose(2 hPG) and postprandial glucose spike of breakfast were significantly higher than those of DM2 group (P<0.05). The standard deviation of blood glucose, mean amplitude of glycemic excursions and absolute means of daily difference were significantly higher in HD group than those of DM2 group(P<0.05). There was no significant difference in percentage of time spent in hyperglycemia above 11.1 mmol/L in the two groups(P>0.05); otherwise the area under the curve of postprandial glucose above 10 mmol/L in HD group was significantly higher than that of DM2 group (P<0.05). The level of fasting insulin in HD group was significantly higher than that of DM2 group (P<0.05), while there was no significant difference in the level of fasting C-peptide in the two groups(P>0.05). Conclusions Compared with type 2 diabetes mellitus, the hepatogenous diabetes have lower fasting plasma glucose and higher postprandial blood glucose. The time of postprandial glucose reaching peak is earlier, and the postprandial glucose spike of breakfast is higher than those of lunch and dinner. The daily blood glucose excursion is more obvious in the patients with hepatogenous diabetes.

Key words: Blood glucose excursion, Hepatogenous diabetes, Continuous glucose monitoring system(CGMS)

CLC Number: 

  • R587
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