JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (8): 68-71.doi: 10.6040/j.issn.1671-7554.0.2014.067

Previous Articles     Next Articles

Preliminary study of magnetic resonance intravoxel incoherent motion in the diagnosis of patients with mild cognitive impairment

DONG Dong1,2, WANG Xinyi3   

  1. 1. School of Medcine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250001, Shandong, China;
    2. Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China;
    3. Department of Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2014-02-11 Revised:2014-06-10 Online:2014-08-10 Published:2014-08-10

PDF (PC)

136

Abstract: Objective To investigate the difference of rCBFivim between the aged people who suffered mild cognitive impairment (MCI) and who showed normal cognition, and to evaluate the value of the intravoxel incoherent motion(IVIM) in the diagnosis of MCI. Methods The patients who visited the Neurology Department of Qianfoshan Hospital Affiliated to Shandong University from July 2012 to May 2013 with complaints of memory loss were enrolled in this study. Twenty MCI patients(MCI group) and 20 individuals with normal cognition(NC group) were performed IVIM detection. The values of D* and f were measured in the areas of both sides of frontal, parietal, occipital lobe, temporal lobe and hippocampus, followed by the calculation of rCBFivim. Results Compared with NC group, rCBFivim significantly decreased in the frontal, parietal, temporal lobe and the area of hippocampus in MCI group (all P<0.05). Compared with NC group, rCBFivim of MCI group also decreased in the cerebellum and occipital lobe, which showed no statistical difference(all P>0.05). Conclusion The intravoxel incoherent motion technique is helpful for the diagnosis of MCI, and it is an useful tool for the assessment of cerebral blood flow in patients with MCI.

Key words: Intravoxel incoherent motion, Magnetic resonance perfusion imaging, Mild cognitive impairment

CLC Number: 

  • R574
[1] Petersen R C, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment[J]. Arch Neurol, 2001, 58(12):1985-1992.
[2] Nobili F, Mazzei D, Dessi B, et al. Unawareness of memory deficit in amnestic MCI: FDG-PET findings[J]. J Alzheimers Dis, 2010, 22(3):993-1003.
[3] Binnewijzend M A, Kuijer J P, Benedictus M R, et al. Cerebral blood flow measured with 3D pseudocontinuous arterial spin-labeling MR imaging in Alzheimer disease and mild cognitive impairment: a marker for disease severity[J]. Radiology, 2013, 267(1):221-230.
[4] Albert M S, DeKosky S T, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease[J]. Alzheimers Dement, 2011, 7(3):263-269.
[5] Moore R J, Issa B, Tokarczuk P, et al. In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T[J]. Magn Reson Med, 2000, 43(2):295-302.
[6] Morvan D. In vivo measurement of diffusion and pseudo-diffusion in skeletal muscle at rest and after exercise[J]. Magn Reson Imaging, 1995, 13(2):193-199.
[7] Le Bihan D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders[J]. Radiology, 1986, 161(2):401-407.
[8] Koh D M, Collins D J, Orton M R. Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges[J]. AJR Am J Roentgenol, 2011, 196(6):1351-1361.
[9] Sasaki M, Sumi M, Van Cauteren M, et al. Intravoxel incoherent motion imaging of masticatory muscles: pilot study for the assessment of perfusion and diffusion during clenching[J]. AJR Am J Roentgenol, 2013, 201(5):1101-1107.
[10] Wirestam R, Borg M, Brockstedt S, et al. Perfusion-related parameters in intravoxel incoherent motion MR imaging compared with CBV and CBF measured by dynamic susceptibility-contrast MR technique[J]. Acta Radiol, 2001, 42(2):123-128.
[11] Torre J C. Impaired cerebromicrovascular perfusion: summary of evidence in support of its causality in Alzheimer's disease[J]. Ann N Y Acad Sci, 2000, 924:136-152.
[12] Dai W, Lopez O L, Carmichael O T, et al. Mild cognitive impairment and Alzheimer disease: patterns of altered cerebral blood flow at MR imaging1[J]. Radiology, 2009, 250(3):856-866.
[13] Alegret M, Cuberas-Borrós G, Vinyes-Junqué G, et al. A two-year follow-up of cognitive deficits and brain perfusion in mild cognitive impairment and mild Alzheimer's disease[J]. J Alzheimers Dis, 2012, 30(1):109-120.
[14] Alsop D C, Casement M, de Bazelaire C, et al. Hippocampal hyperperfusion in Alzheimer's disease[J]. Neuroimage, 2008, 42(4):1267-1274.
[15] 丁蓓，张泳，凌华威，等. 基于体素的动脉自旋标记成像在遗忘型轻度认知障碍患者脑血流灌注中的应用研究[J]. 临床放射学杂志, 2013, 32(1):6-10.
[1] HUANG Fen， JIANG Yu . Correlation between hypertriglyceridemic-waist phenotype and mild cognitive impairment in patients with IGT [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(3): 72-74.
[2] ZHAO Qiang， KANG Yong-jun， WANG Xin-yi， YANG Zhi-qiang. A magnetic resonance diffusion tensor imaging analysis of
 the hippocampus in patients with mild cognitive impairment [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(3): 103-.
[3] MENG Yuanyuan, SHAN Peiyan, LIU Aifen, MA Lin, CHENG Mei， DAI Tingjun. Relationship between metabolic syndrome and mild cognitive impairment in elderly patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(2): 14-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd