JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (4): 64-67.doi: 10.6040/j.issn.1671-7554.0.2015.508

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Vitamin D and mecobalamin combined with mouse nerve growth factor for diabetic peripheral neuropathy: a clinical observation

SHI Rui1, SUN Pei2, WANG Lulu2, DING Lin3, XIA Jin1, WANG Yan3, PANG Shuguang2   

  1. 1. Taishan Medical College, Taian 271000, Shandong, China;
    2. Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    3. School of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2015-05-22 Online:2016-04-10 Published:2016-04-10

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Abstract: Objective To observe the clinical efficacy of vitamin D, mecobalamin and mouse nerve growth factor(mNGF)used in combination for diabetic peripheral neuropathy(DPN). Methods A total of 64 DPN cases were randomly divided into 3 groups. Group A(n=21)received mecobalamin, Group B(n=21)was given mecobalamin combined with vitamin D, Group C(n=22)received vitamin D and mecobalamin combined with mNGF injection. After 4 weeks, all patients’ symptoms and changes of the nerve conduction velocity were recorded. Results The TSS score was reduced and nerve conduction velocity was improved in all 3 groups after treatment, and the difference was statistically significant(P<0.05). Group C had greater reduction in TSS score and increase in nerve conduction velocity than group A and B, and the difference was statistically significant(P<0.05). Conclusion vitamin D and mecobalamin combined with mouse nerve growth factor is effective in the treatment of diabetic peripheral neuropathy.

Key words: Mouse nerve growth factor, Vitamin D, Diabetic peripheral neuropathy, Mecobalamin, Clinical observation

CLC Number: 

  • R587.2
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