JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (4): 64-67.doi: 10.6040/j.issn.1671-7554.0.2015.508

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Vitamin D and mecobalamin combined with mouse nerve growth factor for diabetic peripheral neuropathy: a clinical observation

SHI Rui1, SUN Pei2, WANG Lulu2, DING Lin3, XIA Jin1, WANG Yan3, PANG Shuguang2   

  1. 1. Taishan Medical College, Taian 271000, Shandong, China;
    2. Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    3. School of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2015-05-22 Online:2016-04-10 Published:2016-04-10

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Abstract: Objective To observe the clinical efficacy of vitamin D, mecobalamin and mouse nerve growth factor(mNGF)used in combination for diabetic peripheral neuropathy(DPN). Methods A total of 64 DPN cases were randomly divided into 3 groups. Group A(n=21)received mecobalamin, Group B(n=21)was given mecobalamin combined with vitamin D, Group C(n=22)received vitamin D and mecobalamin combined with mNGF injection. After 4 weeks, all patients’ symptoms and changes of the nerve conduction velocity were recorded. Results The TSS score was reduced and nerve conduction velocity was improved in all 3 groups after treatment, and the difference was statistically significant(P<0.05). Group C had greater reduction in TSS score and increase in nerve conduction velocity than group A and B, and the difference was statistically significant(P<0.05). Conclusion vitamin D and mecobalamin combined with mouse nerve growth factor is effective in the treatment of diabetic peripheral neuropathy.

Key words: Mouse nerve growth factor, Vitamin D, Diabetic peripheral neuropathy, Mecobalamin, Clinical observation

CLC Number: 

  • R587.2
[1] Tesfaye S, Selvarajah D. Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy[J]. Diabetes Metab Res Rev, 2012, 28(S1): 8-14.
[2] Lu B, Yang Z, Wang M, et al. High prevalence of diabetic neuropathy in population-based patients diagnosed with type 2 diabetes in the Shanghai downtown[J]. Diabetes Res Clin Pract, 2010, 88(3): 289-294.
[3] Davies M, Brophy S, Williams R, et al. The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes[J]. Diabetes Care, 2006, 29(7):1518-1522.
[4] Van Acker K, Bouhassira D, De Bacquer D, et al. Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital out patients clinics[J]. Diabetes Metab, 2009, 35(3): 206-213.
[5] Shehab D, Al-Jarallah K, Mojiminiyi OA, et al. Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes?[J]. Diabet Med, 2012, 29(1): 43-49.
[6] Soderstrom LH, Johnson SP, Diaz VA, et al. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES[J]. Diabet Med, 2012, 29(1): 50-55.
[7] Holick MF. Vitamin D deficiency[J]. N Engl J Med, 2007, 357(3): 266-281.
[8] Dey I, Midha N, Singh G, et al. Diabetic Schwann cells suffer from nerve growth factor and neurotrophin-3 underproduction and poor associability with axons[J]. Glia, 2013, 61(12): 1990-1999.
[9] Tosaki T, Kamiya H, Yasuda Y, et al. Reduced NGF secretion by Schwann cells under the high glucose condition decreases neurite outgrowth of DRG neurons[J]. Exp Neurol, 2008, 213(2): 381-387.
[10] Hellweg R, Raivich G, Hartung HD, et al. Axonal transport of endogenous nerve growth factor(NGF)and NGF receptor in experimental diabetic neuropathy[J]. Exp Neurol, 1994, 130(1): 24-30.
[11] Rask CA. Biological actions of nerve growth factor in the peripheral nervoussystem[J]. Eur Neurol, 1999, 41(Suppl 1):14-19.
[12] 李书林, 蒋晓江, 陈曼娥. 大鼠坐骨神经损伤后髓鞘碱性蛋白与神经功能的变化及神经生长因子的影响[J]. 中国临床康复, 2002, 6(6): 798-799. LI Shulin, JIANG Xiaojiang, CHEN Mane. Effects of NGF on the changes of MBP in nervous tissue and the neurological behavior following sciatic nerves injury in rats[J]. Modern Rehabilitation, 2002, 6(6): 768-799.
[13] Kim HC, Cho YJ, Ahn CW, et al. Nerve growth factor and expression of its receptors in patients with diabetic neuropathy[J]. Diabet Med, 2009, 26(12): 1228-1234.
[14] Apfel SC, Kessler JA, Adornato BT, et al. Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group[J]. Neurology, 1998, 51(3): 695-702.
[15] Pilz S, Kienreich K, Rutters F, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes[J]. Curr Diab Rep, 2013, 13(2): 261-270.
[16] Zerwekh JE. Blood biomarkers of vitamin D status[J]. Am J Clin Nutr, 2008, 87(4): S1087-S1091.
[17] Lee P, Chen R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain[J]. Arch Intern Med, 2008, 168(7): 771-772.
[18] Bell DS. Reversal of the symptoms of diabetic neuropathy through correction of vitamin D deficiency in a type 1 diabetic patient[J]. Case Rep Endocrinol, 2012: 165056. doi:10.1155/2012/165056.
[19] Shehab D, Al-Jarallah K, Abdella N, et al. Prospective evaluation of the effect of short-term oral vitamin D supplementation on peripheral neuropathy in type 2 diabetes mellitus[J]. Med Princ Pract, 2015, 24(3): 250-256.
[20] Brown J, Bianco I, McGrath JJ, et al. 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons[J]. Neurosci Lett, 2003, 343(2): 139-143.
[21] Cornet A, Baudet C, Neveu I, et al. 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro[J]. J Neurosci Res, 1998, 53(6): 742-746.
[22] Cheng HT, Dauch JR, Hayes JM, et al. Nerve growth factor mediates mechanical allodynia in a mouse model of type 2 diabetes[J]. Neuropathol Exp Neurol, 2009, 68(11): 1229-1243.
[23] Rukwied R, Mayer A, Kluschina O, et al. NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin[J]. Pain, 2010, 148(3): 407-413.
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