Abstract: Objective To evaluate the diagnostic value of dual-phase PET/CT in the differential diagnosis of benign and malignant pancreatic lesions. Methods The ¹⁸F-FDG PET/CT conventional imaging was performed on 81 cases of malignant pancreatic lesions and 41 cases of benign pancreatic lesions. Of them, 46 of the malignant cases and 22 of the benign cases received delayed imaging. The best cut-off point value of maximum standardized uptake value for early phase(SUV_early)and retention index(RI)were explored. Results Among the 122 cases undergoing ¹⁸F-FDG PET / CT examination, SUV_early of malignant cases(5.46±3.51)was significantly higher than that of benign cases(1.89±1.28)(P<0.05), while SUV_delay of malignant cases(5.87±3.79)was higher than that of benign cases(2.64±1.94)(P<0.05). Among the 68 cases undergoing the dual-phase PET/CT, there was no significant difference between SUV_early(2.33±1.25)and SUV_delay(2.64±1.94)in benign cases(P>0.05), while in malignant cases, SUV_delay(5.87±3.79)was significantly higher than SUV_early(4.52±2.98)(P<0.05). According to the ROC curve, when the best cut-off value of SUV_early was 2.75, the sensitivity, specificity and accuracy were 82.72%, 80.49% and 81.97% respectively. When RI%=12.04% was set as the boundary value, the sensitivity, specificity and accuracy were 82.61%, 72.72% and 79.41%, respectively. When SUV_early=2.75 and RI%=12.04% were jointly considered, the 山 东 大 学 学 报 (医 学 版)54卷4期 -孙旭怡,等.¹⁸F-FDG PET/CT双时相显像对胰腺良恶性病变鉴别的诊断价值 \=-sensitivity, specificity and accuracy were 93.48%, 59.10% and 82.35%, respectively. Conclusion ¹⁸F-FDG dual-phase PET/CT has a good diagnostic value in differentiating benign pancreatic lesions from malignant ones.

Key words: Pancreatic cancer, ¹⁸F-FDG, Dual-Phase, Standardized uptake value, PET/CT