JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (10): 40-45.doi: 10.6040/j.issn.1671-7554.0.2015.1282

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Correlation between serum amyloid A and cognitive function of patients with acute cerebral infarction

MI Te, QU Chuanqiang, WANG Xiang, YIN Ling, XUE Yuan, DU Yifeng   

  1. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2015-12-15 Online:2016-10-10 Published:2016-10-10

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Abstract: Objective To explore the relationship between human serum amyloid A(SAA)and cognitive function of patients with acute cerebral infarction. Methods A total of 105 patients with acute cerebral infarction diagnosed in Department of Neurology of Shandong Provincial Hospital were selected and their cognitive functions were assessed by mini-mental state examination(MMSE). According to different education time, the patients were divided into two groups, education time <6 years group(n=36)and ≥6 years group(n=69). Correlations between SAA and each influencing factor, including age, gender, education level, smoking and other cerebrovascular risk factors, as well as SAA and each cognitive domain in MMSE were analyzed. Results The scores of MMSE, time and place orientation, short-term memory and graphic execution in education time <6 years group were all significantly lower than those in education time ≥6 years group(P<0.05 or P<0.01). In cognitive assessment, the differences in the scores of time and place orientation were statistically significant among the patients with infarctions of anterior circulation(n=53), posterior circulation(n=44), or anterior and posterior circulation(n=8)(P<0.05). Spearman correlation analysis revealed that SAA was positively correlated with α2-MG(r=0.29, P<0.01). Generalized liner regression analysis 山 东 大 学 学 报 (医 学 版)54卷10期 -宓特,等.血清淀粉样蛋白A与脑梗死急性期认知功能的相关性 \=-displayed that SAA was related to the decreases of time and place orientation as well as computing capability(P<0.05 or P<0.01). Conclusion The increasing level of serum SAA is associated with cognitive impairment of patients with acute cerebral infarction, especially disturbance of time and place orientation as well as computing capability.

Key words: Serum amyloid A, Mini-mental state examination, Orientation, Cognitive impairment, Acute cerebral infarction

CLC Number: 

  • R743.3
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