JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (10): 40-45.doi: 10.6040/j.issn.1671-7554.0.2015.1282

Previous Articles     Next Articles

Correlation between serum amyloid A and cognitive function of patients with acute cerebral infarction

MI Te, QU Chuanqiang, WANG Xiang, YIN Ling, XUE Yuan, DU Yifeng   

  1. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2015-12-15 Online:2016-10-10 Published:2016-10-10

PDF (PC)

391

Abstract: Objective To explore the relationship between human serum amyloid A(SAA)and cognitive function of patients with acute cerebral infarction. Methods A total of 105 patients with acute cerebral infarction diagnosed in Department of Neurology of Shandong Provincial Hospital were selected and their cognitive functions were assessed by mini-mental state examination(MMSE). According to different education time, the patients were divided into two groups, education time <6 years group(n=36)and ≥6 years group(n=69). Correlations between SAA and each influencing factor, including age, gender, education level, smoking and other cerebrovascular risk factors, as well as SAA and each cognitive domain in MMSE were analyzed. Results The scores of MMSE, time and place orientation, short-term memory and graphic execution in education time <6 years group were all significantly lower than those in education time ≥6 years group(P<0.05 or P<0.01). In cognitive assessment, the differences in the scores of time and place orientation were statistically significant among the patients with infarctions of anterior circulation(n=53), posterior circulation(n=44), or anterior and posterior circulation(n=8)(P<0.05). Spearman correlation analysis revealed that SAA was positively correlated with α2-MG(r=0.29, P<0.01). Generalized liner regression analysis 山 东 大 学 学 报 (医 学 版)54卷10期 -宓特,等.血清淀粉样蛋白A与脑梗死急性期认知功能的相关性 \=-displayed that SAA was related to the decreases of time and place orientation as well as computing capability(P<0.05 or P<0.01). Conclusion The increasing level of serum SAA is associated with cognitive impairment of patients with acute cerebral infarction, especially disturbance of time and place orientation as well as computing capability.

Key words: Serum amyloid A, Mini-mental state examination, Orientation, Cognitive impairment, Acute cerebral infarction

CLC Number: 

  • R743.3
[1] Jia J, Wang F, Wei C, et al. The prevalence of dementia in urban and rural areas of China[J]. Alzheimers Dement, 2014, 10(1):1-9.
[2] Chan KY, Wang W, Wu JJ, et al. Epidemiology of Alzheimers disease and other forms of dementia in China. 1990-2010: a systematic review and analysis[J]. Lancet, 2013, 381(9882): 2016-2023.
[3] Mukhopadhyay A, Sundar U, Adwani S, et al. Prevalence of stroke and post-stroke cognitive impairment in the elderly in Dharavi, Mumbai[J]. J Assoc Physicians India, 2012, 60(60): 29-32.
[4] Jacquin A, Binquet C, Rouaud O, et al. Post-stroke cognitive impairment: high prevalence and determining factors in a cohort of mild stroke[J]. J Alzheimers Dis, 2014, 40(4): 1029-1038.
[5] Brayne C. The elephant in the room-healthy brains in later life, epidemiology and public health[J]. Nat Rev Neurosci, 2007, 8(3): 233-239.
[6] Savva GM, Stephan BC. Alzheimers society vascular dementia systematic review G. Epidemiological studies of the effect of stroke on incident dementia: a systematic review[J]. Stroke, 2010, 41(1): e41-46.
[7] Sezer S, Uçar F, Ulusoy EK, et al. Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers[J]. Turk J Med Sci, 2014, 44(1): 16-23.
[8] Marksteiner J, Imarhiagbe D, Defrancesco M, et al. Analysis of 27 vascular-related proteins reveals that NT-proBNP is a potential biomarker for Alzheimers disease and mild cognitive impairment: a pilot-study[J]. Exp Gerontol, 2014, 50: 114-121. doi:10.1016/j.exger.2013.12.001.
[9] Zeng Q, Tao W, Lei C, et al. Etiology and risk factors of posterior circulation infarction compared with anterior circulation infarction[J]. J Stroke Cerebrovasc Dis, 2015, 24(7): 1614-1620.
[10] Trollor JN, Smith E, Agars E, et al. The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study[J]. Age(Dordr), 2012, 34(5): 1295-1308.
[11] Renjen PN, Gauba C, Chaudhari D. Cognitive impairment after stroke[J]. Cureus, 2015, 7(9): e335. doi:10.7759/cureus.335.
[12] Stephens S, Kenny RA, Rowan E, et al. Neuropsychological characteristics of mild vascular cognitive impairment and dementia after stroke[J]. Int J Geriatr Psychiatry, 2004, 19(11):1053-1057.
[13] Bour A, Rasquin S, Boreas A, et al. How predictive is the MMSE for cognitive performance after stroke?[J]. J Neurol, 2010, 257(4): 630-637.
[14] Meng X, DArcy C. Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses[J]. PLoS One, 2012, 7(6): e38268. doi:10.1371/journal.pone.0038268.
[15] Skogen B, Natvig JB. Degradation of amyloid proteins by different serine proteases[J]. Scand J Immunol, 1981, 14(4): 389-396.
[16] Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association[J]. Circulation, 2003, 107(3): 499-511.
[17] Pessolano LJ, Sullivan CP, Seidl SE, et al. Trafficking of endogenous smooth muscle cell cholesterol: a role for serum amyloid A and inter-leukin 1β[J]. Arterioscler Thromb Vasc Biol, 2012, 32(11): 2741-2750.
[18] Losey P, Ladds E, Laprais M, et al. The role of PPAR activation during the systemic response to brain injury[J]. J Neuroinflammation, 2015, 12(1): 99. doi:10.1186/s12974-015-0295-7.
[19] Dong Z, Wu T, Qin W, et al. Serum amyloid A directly accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice[J]. Mol Med, 2011, 17(11-12): 1357-1364.
[20] Li B, Dong Z, Liu H, et al. Serum amyloid A stimulates lipoprotein-associated phospholipase A2 expression in vitro and in vivo[J]. Atherosclerosis, 2013, 228(2): 370-379.
[21] Elkind MS, Coates K, Tai W, et al. Levels of acute phase proteins remain stable after ischemic stroke[J]. BMC Neurol, 2006, 6: 37. doi:10.1186/1471-2377-6-37.
[22] Brea D, Sobrino T, Blanco M, et al. Usefulness of haptoglobin and serum amyloid A proteins as biomarkers for atherothrombotic ischemic stroke diagnosis confirmation[J]. Atherosclerosis, 2009, 205(2): 561-567.
[23] Schillinger M, Exner M, Mlekusch W, et al. Inflammation and carotid artery-risk for atherosclerosis study(ICARAS)[J]. Circulation, 2005, 111(17): 2203-2209.
[1] ZHANG Yunhua, LI Jie. Diagnostic value of the level of plasma lipoprotein-associated phospholipase A2 and the CEU degree of neovascularization of carotid artery plaque in acute cerebral infarction [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 112-116.
[2] DONG Fang, DU Yifeng. Correlation among cognitive impairment and high homocysteinemia as well as the number and volume of infarct in patients with lacunar cerebral infarction [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 46-49.
[3] LIU Guangyun, CONG Lin, GUO Shougang. Characteristics of cognitive impairment in patients with multiple sclerosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(10): 51-54.
[4] DONG Dong, WANG Xinyi. Preliminary study of magnetic resonance intravoxel incoherent motion in the diagnosis of patients with mild cognitive impairment [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(8): 68-71.
[5] WANG Jianli1, ZHANG Yong2, ZHU Yuanyuan3, LI Bin2， GUAN Yichao1， GENG Ting4. A correlation study between aspirin resistance and  platelet miR126 in acute cerebral infarction patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(5): 77-81.
[6] HUANG Fen， JIANG Yu . Correlation between hypertriglyceridemic-waist phenotype and mild cognitive impairment in patients with IGT [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(3): 72-74.
[7] LI Ning, DENG Hongqiong, WANG Cuilan. Changes and significance of serum Hs-CRP and SAA in patients with progressive cerebral infarction [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(10): 45-48,60.
[8] ZHANG Min1, GENG Hou-fa2, SUN Lin2. Quantitative evaluation of brain metabolic changes in patients with acute cerebral infarction and type 2 diabetes mellitus using proton magnetic resonance spectroscopy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(11): 74-77.
[9] ZHANG Hui-feng1， ZHOU Jia-long1， SHENG Wen-hua2，3. Relationship between blood glucose level and PSGL-1 expression in acute cerebral infarction patients with type 2 diabetes mellitus and its significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(10): 66-69.
[10] ZHAO Qiang， KANG Yong-jun， WANG Xin-yi， YANG Zhi-qiang. A magnetic resonance diffusion tensor imaging analysis of
 the hippocampus in patients with mild cognitive impairment [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(3): 103-.
[11] MENG Yuanyuan, SHAN Peiyan, LIU Aifen, MA Lin, CHENG Mei， DAI Tingjun. Relationship between metabolic syndrome and mild cognitive impairment in elderly patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(2): 14-.
[12] . Correlation between mild cognitive impairment and advanced glycosylation 
end product level in type 2 diabetic patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(9): 11-13.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd