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A correlation study between aspirin resistance and  platelet miR126 in acute cerebral infarction patients

WANG Jianli1, ZHANG Yong2, ZHU Yuanyuan3, LI Bin2， GUAN Yichao1， GENG Ting4   

  1. 1. School of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Geriatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    3. Department of Hematology Laboratory, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    4. Weifang Medical College, Weifang 261053, Shandong, China
  • Received:2013-11-27 Online:2014-05-10 Published:2014-05-10

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Abstract: Objective  To investigate the correlation between platelet miR126 and aspirin resistance (AR) in acute cerebral infarction patients. Methods  Fifty-one patients with acute cerebral thrombosis were treated as the case group, and sixty volunteers of non-cerebral infarction and non-myocardial infarction were treated as the control group. The AR and non-aspirin resistance (NAR) were distinguished by the platelet aggregation experiments, and the levels of miR126 were detected by RT-PCR assay. Results  miR126 levels in the case group were less than those in the control group (P<0.05). miR126 levels of AR were significantly higher than those of NAR in the control group (P<0.05). Conclusion  Platelet miR126 levels of acute cerebral infarction patients are lower than the volunteers, however, it is not related to AR of patients. Lower level of platelet miR126 prompts acute cerebral infarction to some extent.

Key words: Non-aspirin resistance, Acute cerebral infarction, miR126, Aspirin resistance

CLC Number: 

  • R741.02
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