JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (10): 45-48,60.doi: 10.6040/j.issn.1671-7554.0.2014.342

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Changes and significance of serum Hs-CRP and SAA in patients with progressive cerebral infarction

LI Ning1, DENG Hongqiong1, WANG Cuilan2   

  1. 1. Department of Neurology, Jinan Third People's Hospital, Jinan 250101, Shandong, China;
    2. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-05-27 Revised:2014-09-25 Online:2014-10-10 Published:2014-10-10

Abstract: Objective To investigate changes and significance of serum high-sensitivity C-reactive protein (Hs-CRP) and serum amyloid A protein (SAA) in patients with progressive cerebral infarction (PCI). Methods A total of 107 participants were divided into 3 groups: PCI group (n=34), non-progressive cerebral infarction (NPCI) group (n=33) and control group (people with vascular risk factors who received clinical examinations, n=34). Hs-CRP levels were measured with immune nephelometry, and SAA levels were evaluated with enzyme-linked immunosorbent assay (ELISA). Patients were rated with the Scandinavian Stroke Scale (SSS) score. Results Compared with the NPCI group and controls, the Hs-CRP and SAA levels in the PCI group significantly increased on day 1, 3, 7, and 14 (all P<0.01). In the PCI group, Hs-CRP and SAA levels were positively correlated (P<0.01), and Hs-CRP and SAA levels one day 1 were negative correlated with the SSS on day 3 and 21 (all P<0.05). Conclusion Levels of Hs-CRP and SAA are significantly enhanced in PCI patients, which are closely related with the severity of disease, suggesting that Serum Hs-CRP and SAA play an important role in the progression of PCI.

Key words: Non-progressive cerebral infarction, Serum amyloid A protein, Progressive cerebral infarction, High-sensitivity C-reactive protein

CLC Number: 

  • R741
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