JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (10): 45-48,60.doi: 10.6040/j.issn.1671-7554.0.2014.342

Previous Articles     Next Articles

Changes and significance of serum Hs-CRP and SAA in patients with progressive cerebral infarction

LI Ning1, DENG Hongqiong1, WANG Cuilan2   

  1. 1. Department of Neurology, Jinan Third People's Hospital, Jinan 250101, Shandong, China;
    2. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-05-27 Revised:2014-09-25 Online:2014-10-10 Published:2014-10-10

PDF (PC)

235

Abstract: Objective To investigate changes and significance of serum high-sensitivity C-reactive protein (Hs-CRP) and serum amyloid A protein (SAA) in patients with progressive cerebral infarction (PCI). Methods A total of 107 participants were divided into 3 groups: PCI group (n=34), non-progressive cerebral infarction (NPCI) group (n=33) and control group (people with vascular risk factors who received clinical examinations, n=34). Hs-CRP levels were measured with immune nephelometry, and SAA levels were evaluated with enzyme-linked immunosorbent assay (ELISA). Patients were rated with the Scandinavian Stroke Scale (SSS) score. Results Compared with the NPCI group and controls, the Hs-CRP and SAA levels in the PCI group significantly increased on day 1, 3, 7, and 14 (all P<0.01). In the PCI group, Hs-CRP and SAA levels were positively correlated (P<0.01), and Hs-CRP and SAA levels one day 1 were negative correlated with the SSS on day 3 and 21 (all P<0.05). Conclusion Levels of Hs-CRP and SAA are significantly enhanced in PCI patients, which are closely related with the severity of disease, suggesting that Serum Hs-CRP and SAA play an important role in the progression of PCI.

Key words: Non-progressive cerebral infarction, Serum amyloid A protein, Progressive cerebral infarction, High-sensitivity C-reactive protein

CLC Number: 

  • R741
[1] Ong C T, Wu C S. Neurological deterioration in patients with first ever ischemic stroke[J]. Acta Neurol Taiwan, 2007, 16(3): 143-149.
[2] Rajeshwar K, Kaul S, Al-Hazzani A, et al. C-reactive protein and nitric oxide levels in ischemic stroke and its subtypes: correlation with clinical outcome[J]. Inflammation, 2012, 35(3): 978-984.
[3] Lukasik M, Dworacki G, Kufel-Grabowska J, et al. Up regulation of CD40 ligand and enhanced monocyte-platelet aggregate formation are associated with worse clinical outcome after ischemic stroke[J]. Thromb Haemost, 2012, 107(2): 346-355.
[4] Mao D J, Guo R Y, Tang Y C, et al. Expression of sCD40L in peripheral blood and NF-κBp65 in PBMC of patients with acute progressive cerebral infarction[J]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011, 27(2): 177-179.
[5] O'Brien K D, Chait A. Serum amyloid A: the "other" inflammatory protein[J]. Curr Atheroscler Rep, 2006, 8(1): 62-68.
[6] Hua S, Song C, Geczy C L, et al. A role for acute-phase serum amyloid A and high-density lipoprotein in oxidative stress, endothelial dysfunction and atherosclerosis.A role for acute-phase serum amyloid and high-density[J]. Redox Rep, 2009, 14(5): 187-196.
[7] 魏衡, 杜继臣, 张绿明, 等. 血清淀粉样蛋白A与缺血性脑卒中及亚型的相关性研究[J]. 中国神经免疫学和神经病学杂志, 2010, 3(19): 183-186. WEI Heng, DU Jichen, ZHANG Lüming, et al. Association between ischemic stroke and serum amyloid A protein[J]. Chin J Neuroimmunol &Neurol, 2012, 3(19): 183-186.
[8] Liuzzo G, Biasucci L M, Gallimore J R, et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina[J]. N Engl J Med, 1994, 331(7): 417-424.
[9] Brea D, Sobrino T, Blanco M, et al. Usefulness of haptoglobin and serum amyloid A proteins as biomarkers for atherothrombotic ischemic stroke diagnosis confirmation[J]. Atherosclerosis, 2009, 205(2): 561-567.
[10] 中华神经科学会中华神经外科学会. 各类脑血管疾病诊断要点[J]. 中华神经科杂志, 1996, 29(6): 379-380.
[11] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组. 中国急性缺血性脑卒中诊治指南2010[J]. 中华神经科杂志, 2010, 2(43): 146-153.
[12] Birschel P, Ellul J, Barer D, et al. Progressing stroke: towards an internationally agreed definition[J]. Cerebrovasc Dis, 2004, 17(2-3): 242-252.
[13] 张春华, 王炳莲, 田国栋. 高敏C-反应蛋白与进展性脑梗死相关性的临床观察[J]. 中国现代神经疾病杂志, 2010, 5(10): 583-584.
[14] 木崇仙. 超敏C反应蛋白、纤维蛋白原与进展性卒中的相关性[J].中国现代药物应用, 2012, 7(6):21-23.
[15] Kim S K, Song P, Hong J M, et al. Prediction of progressive motor deficits in patients with deep subcortical infarction[J]. Cerebrovasc Dis, 2008, 25(4): 297-303.
[16] Ridker P M, Danielson E, Fonseca F A, et al. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial[J]. Lancet, 2009, 373(9670): 1175-1182.
[17] Wang L, Colón W. The interaction between apolipoprotein serum amyloid A and high-density lipoprotein[J]. Biochem Biophys Res Commun, 2004, 317(1): 157-161.
[18] 战晶晶, 金丽英, 王海萍, 等. 缺血性脑血管病病人SAA水平检测与意义[J]. 青岛大学医学院学报, 2011, 47(2): 110-112.
ZHAN Jingjing, JIN Liying, WANG Haiping, et al. Determination and significance of saa in patients with ischemic cerebrovascular disease[J]. Acta Academiae Medicinae Qingdao Universitatis, 2011, 47(2): 110-112.
[19] Rallidis L S, Vikelis M, Panagiotakos D B, et al. Inflammatory markers and in-hospital mortality in acute ischemic stroke.Inflammatory markers and in-hospital mortality in acute ischemic stroke[J]. Atherosclerosis, 2006, 189(1): 193-197.
[20] 李骞. 不同剂量瑞舒伐他汀对动脉粥样硬化大鼠SAA、hs-CRP水平的影响[J]. 当代医学, 2012, 5(18): 131-132.
[21] 李强, 凌芳, 聂德云, 等. 阿托伐他汀对急性脑梗死患者血脂和血清妊娠相关蛋白A等炎性因子的影响[J]. 中国脑血管病杂志, 2011, 8(6): 308-311.
LI Qiang, LING Fang, NIE Deyun, et al. Effects of intensive lipid-lowering therapy on the changes of serum pregnancy-associated plasma protein levels in patients with acute cerebral infarction[J]. Chin J Cerebrovasc Dis, 2011, 8(6): 308-311.
[1] XU Yuxiang, LIU Yudong, ZHANG Peng, DUAN Ruisheng. A retrospective analysis of risk factors of cerebral microbleeds in 101 patients with cerebral small vessel disease [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 67-71.
[2] WANG Yuan-yuan,LI Li,ZHOU Feng-hua,MENG Xiao,ZHONG Ming,ZHANG Wei,ZHANG Yun. Clinical significance of neutrophil myeloperoxidase on peripheral circulation in acute coronary syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(10): 996-999.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd