Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (1): 1-5.doi: 10.6040/j.issn.1671-7554.0.2021.0275

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Hydrogen sulfide alleviates acute obstructive sleep apnea-induced atrial fibrillation by regulating oxidative stress through glutaredoxin-1

HUANG Huining1,2, DU Juanjuan2, SUN Yi2, HOU Yinglong2, GAO Mei1,2   

  1. 1. The Second Clinical College of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China;
    2. Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong, China
  • Published:2022-01-08

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Abstract: Objective To explore the mechanism of hydrogen sulfide(H2S)alleviating atrial fibrillation(AF)induced by acute obstructive sleep apnea(OSA). Methods Sodium hydrosulfide(NaHS)was used as exogenous H2S donor, and 24 healthy adult male SD rats(aged 8-10 weeks)weighing 320 g to 360g were randomly divided into control group, OSA-induced AF group, NaHS+OSA group and cadmium chloride+NaHS+OSA group, with 6 in each group. The model of AF induced by OSA was established according to previous literature. The rats were sacrificed and left atrial appendages were collected. The expression of glutaredoxin-1 was detected with immunofluorescence and ELISA, and the content of malondialdehyde(MDA)was detected with thiobarbituric acid. Results Compared with the OSA group, the NaHS+OSA group had decreased frequency of AF and shortened duration of AF(P<0.05). Compared with control group, the OSA group had decreased expression of glutaredoxin-1 but increased MDA content. After NaHS was used, the expression of glutaredoxin-1 increased but the MDA content decreased compared with the OSA group(P<0.01). After cadmium chloride was used, the MDA content increased(P<0.01), and the effect of H2S on alleviating OSA-induced AF disappeared. Conclusion Exogenous application of H2S alleviate acute OSA-induced AF by regulating oxidative stress through glutaredoxin-1.

Key words: Atrial fibrillation, Obstructive sleep apnea, Hydrogen sulfide, Glutaredoxin-1, Oxidative stress

CLC Number: 

  • R541.7
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