JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (10): 76-83.doi: 10.6040/j.issn.1671-7554.0.2017.039

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Meta-analysis and system evaluation of 125I implantation in the treatment of early lung cancer

WANG Lili, HUO Bin, WANG Lei, WANG Hao, HOU Dingkun, HUO Xiaodong, WANG Jinhuan, ZANG Li, CAO Qiang, CHAI Shude, WANG Haitao   

  1. Department of Oncology, Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Received:2017-01-11 Online:2017-10-10 Published:2017-10-10

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Abstract: Objective To evaluate the efficacy of sublobar resection(SR)and sublobar resection combined with 125I brachytherapy(SRB)in the treatment of early non-small cell lung cancer(NSCLC). Methods The relevant literatures on SR and SRB in the treatment of NSCLC were searched in PubMed, Embase, Cochrane Library, CNKI, Wanfang database, and Chinese CBM database from the inception date to Nov. 2016. The bibliographies of retrieved articles were also enrolled. The studies enrolled were classified, the quality was evaluated, and data were extracted. Results A total of 16 studies(n=1 354)were included, 4 of which compared the efficacy of SR and SRB in the treatment of NSCLC, and 12(n=742)recorded SRB in the treatment of NSCLC. Meta-analysis showed that there was no statistical difference although SRB could reduce local recurrence(P=0.06). For SRB, the local control rate was 96.1%; the probability of local recurrence / distant metastases was 19.1%; the mean survival rate of 1-year, 2-year and 5-year was 84.9%, 74.9% and 32.1%, respectively. Conclusion The evidence shows that SRB is effective in the treatment of NSCLC, which can reduce the local recurrence rate. However, more high-quality studies are needed to confirm the efficacy.

Key words: 125I implantation, Early non-small cell lung cancer, Efficacy, System evaluation, Sublobar resection, Meta-analysis

CLC Number: 

  • R734.2
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