JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (10): 84-89.doi: 10.6040/j.issn.1671-7554.0.2017.167

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Association between high expression of scavenger receptor class B type I and the prognosis of colon cancer

LIU Huiling1, WANG Xingwen1, FENG Shaobin2, FENG Hong1, HAN Junqing1   

  1. 1. Cancer Center, Shandong Provincial Hospital Affiliated of Shandong University;
    2. Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2017-02-23 Online:2017-10-10 Published:2017-10-10

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Abstract: Objective To explore the association between the expression of scavenger receptor class B type I(SR-BI)and the clinicopathological variables, and to determine whether SR-BI expression was an independent prognostic factor and a potential therapeutic target for colon cancer. Methods A well-documented tissue microarray of 90 patients with colon cancer was purchased from Shanghai Outdo Biotech Co., Ltd. The SR-BI expression in the cancer tissues and para-cancerous tissues were detected with immunohistochemical method. The association between SR-BI expression and the clinicopathological variables, and patients outcome was analyzed. Results In 78.9% of the cases, SR-BI expression was higher in the cancer tissues than in the adjacent non-tumor tissues(P<0.001). The expression of SR-BI in colon cancer tissues had no significant statistical association with the clinicopathological variables. Patients with low SR-BI expression in colon cancer tissues had a shorter overall survival(OS)than those with high SR-BI expression(P=0.042). The multivariate analysis confirmed that high SR-BI expression was an independent favorable prognostic factor for OS(P=0.039). Conclusion Low SR-BI expression is associated with unfavorable prognosis of colon cancer. SR-BI is an independent prognostic factor of colon cancer.

Key words: Colon cancer, Prognosis, Scavenger receptor class B type I, Immunohistochemistry

CLC Number: 

  • R735.3
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