JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Association between two concurrent gene polymorphisms and type 2 diabetes with macro-angiopathy

ZOU Cai-yan1, LI Yin-yin1,　LI Qiu1,　CHEN Han-yan1,　WANG Lai-cheng2,　LV Xiao-xia2   

  1. 1. Department of Health Care Eendocrine; 2. Department of Scientific Research, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2008-01-08 Revised:1900-01-01 Online:2008-06-16 Published:2008-06-16
  • Contact: LI Yin-yin

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Abstract: To investigate the correlation between polymorphisms of both +299G/A at resistin gene and Pro12Ala at PPARγ2 gene and diabetic macro-angiopathy. MethodGenotypes and alleles of polymorphisms of both genes were determined with polymerase chain reactionrestriction fragment length polymorphism assay (PCRRFLP) of 296 subjects in Han Chinese. Results Both resistin gene +299G/A alleles frequencies in group A (the type 2 diabetes group) and alleles frequencies and genotypes in group B(the type 2 diabetes combined with the macroangiopathy group) were statistically significant from those in the control group(P＜0.05), but P/A alleles frequencies and genotypes to of the PPARγ2 gene were statistically different in groups A (P＞0.05 vs the control group) and were statistically different in group B (P＜0.05 vs the control and the A group). Type 2 diabetes with the coexistence of the A allele/AA genotype of resistin gene and the A allele/PA genotype of the PPARγ2 gene had a lower incidence of macro-angiopathy than those with one gene alone or without the gene(P＜0.05). ConclusionThe A allele/AA genotype at resistin gene of +299 and the Ala allele at the PPARγ2 gene of Pro12Ala are related to diabetic macroangiopathy.

Key words: Diabetes mellitus, non-insulin-dependent, Vascular diseases, Resistin, Polymorphism, single nucleotide

CLC Number: 

  • R587.1
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