JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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The association between genetic polymorphism of superroxide dismutase and chronic obstructive pulmonary diseases

HAN Yi-qun1，XUE Yu-wen2，LI Chuan-fen3，CHE Bo4   

  1. 1． School of Medicine， Shandong University;2． Department of Respiratory， Qilu Hospital of Shandong University;3． Department of Laboratory Diagnosis， General Hospital of Jinan Military Command;4． Department of Medicine， Feicheng People′s Hospital
  • Received:2007-04-17 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
  • Contact: XUE Yu-wen

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Abstract: Objective： To explore the association of genetic polymorphism of superoxide dismutase（SOD） and chronic obstructive pulmonary diseases（COPD）. Methods： 70 patients with COPD （the COPD group）and 70 healthy volunteers (the control group ) were enrolled in this study. Limosis peripheral blood was taken and whole blood corpuscle genomic DNA was extracted. The genetic polymorphism of SOD1-3 genes was determined by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP). Result： There were no logistic differences between the COPD and the control groups in the genetic polymorphism of SOD1（CuZn-SOD） and SOD2（Mn-SOD）, however, there were logistic differences in the genetic polymorphism of SOD3（EC-SOD）（P＜0.05）. Conclusion： SOD3（EC-SOD）genetic polymorphism (C+760G，Arg213Gly) is related to the development of COPD and it may be the COPDrelated gene.

Key words: Superoxide dismutase, Genetic polymorphism, Chronic obstructive pulmonary disease, Polymerase chain reaction, Polymorphism, restriction fragment length

CLC Number: 

  • R392.21
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