JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression of HSP70 and Caspase3 in human glioma and its relationship with pathological grades

ZHENG Hong， GENG Ming   

  1. Graduate School of Shandong University， The Forth Department of Cadre Ward,Military General Hospital of Jinan Command, Jinan 250031, Shandong, China
  • Received:2007-03-16 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
  • Contact: GENG Ming

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Abstract: Objective: To explore the correlation between Caspase3 and HSP70 expressions and biologic behaviors and pathological grades of human glioma. Methods: Expressions of Caspase3 and HSP70 and their correlation in human glioma were determined by immunohistochemistry(SP). Results: With the increase of tumor clinical grades，the positive rate of HSP70 was increased and the negative rate of Caspase3 was decreased. Expression rates of HSP70 were 25%, 69%, 92% and 100% in grades of Ⅰ-Ⅳ and expression rates of Caspase3 were 87.5%, 61.5%, 38.5% and 31% in grades of Ⅰ-Ⅳ. There was a negative correlation between Caspase3 and HSP70 expression. Conclusion: Expressions of Caspase3 and HSP 70 are correlated with biological behavior and cell differentiation degrees of glioma. They are important markers for the evaluation of prognosis in glioma.

Key words: Glioma, HSP70, Caspase3, Immunohistochemistry

CLC Number: 

  • R739.34
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