JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (11): 82-86.doi: 10.6040/j.issn.1671-7554.0.2015.777

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Epidemiological characteristics of hemorrhagic fever with renal syndrome patients in Huangdao District of Qingdao City, China from March, 2012 to February, 2013

ZHANG Zhentang1, FANG Lizhu2, XUE Zaifeng1, ZHAO Li2, MA Dongqiang1, WEN Hongling2, LIU Jianwei2, ZHANG Xiaoshuang2, YU Xuejie2   

  1. 1. Department of Prevention and Control of Infectious Disease, Center for Disease Control and Prevention of Huangdao District, Huangdao 266400, Shandong, China;
    2. Department of Microorganism Examination, School of Public Health, Shandong University, Jinan 250012, Shandong, China
  • Received:2015-08-18 Online:2016-11-10 Published:2016-11-10

Abstract: Objective To investigate the incidence and epidemiological feature of hemorrhagic fever with renal syndrome(HFRS)from March, 2012 to February, 2013 in Huangdao District, Qingdao City and provide the data for the prevention and control of HFRS. Methods A total of 106 acute phase sera of suspected HFRS patients were collected from Huangdao District. These samples were analyzed for Hantavirus(HV)IgM antibodies and RNA through ELISA and nested RT-PCR respectively. HV RNA positive samples were used for genotypic assay. Results Twenty sera of one hundred and six acute phase sera were positive to HV-IgM antibody, and 2 sera were positive to Hantanvirus(HTN)RNA. One of the sera is positive validated by nested RT-PCR, as well as by ELISA. So the total positive number is 21, and the total positive rate was 19.8%. Among these patients, 14 were male and 7 were female, most of whom belonged to the 45-59 year-old group. The disease had mostly occurred in autumn with 16 positive cases and there were also sporadic cases in other seasons. Five of the twenty-one sera were positive in Zangnan County from March, 2012 to February, 2013 and other counties still had some cases. Conclusion In Huangdao District of Qingdao 山 东 大 学 学 报 (医 学 版)54卷11期 -张振堂,等.2012年3月~2013年2月青岛市黄岛区肾综合征出血热流行特征 \=-City, HFRS mainly occurrs in autumn and most patients are middle-age men.

Key words: Serological test, Reverse transcription polymerase chain reaction, Hantavirus, Hemorrhagic fever with renal syndrome

CLC Number: 

  • R181.3
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