JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression of CD34 and PTTG relates to pituitary adenomas with invasion of the cavernous sinus space

HU Jia, QU Yuan-ming, HAN Tao, MU Cheng-zhi   

  1. Department of Neurosurgery, Shandong Pronvincial Hospital, Shandong University, Jinan 250021, Shandong, China
  • Received:2006-12-12 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
  • Contact: HU Jia

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Abstract: Objective: To investigate the characteristics of CD34 and PTTG expression in pituitary adenomas with invasion of the cavernous sinus space. Methods：Sixty-two patients with large pituitary adenomas were divided into groups based on the Knosp criteria. Expression of CD34 and PTTG was determined by immunohistochemical method. Results： The mean microvascular density (MVD) of tumors which surpassed the laternal marginal level of ICA was 44.04，and their PTTG exceeding (+Conclusion: Pituitary adenomas surpassing the laternal marginal level of ICA have strong expression of MVD and PTTG and strong invasiveness, so they are difficult to remove completely and should be treated with radiotherapy or drugs after surgery.

Key words: Pituitary neoplasms, Cavernous sinus, Invasiveness, Immunohistochemistry

CLC Number: 

  • R739.41
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