JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (2): 78-81.doi: 10.6040/j.issn.1671-7554.0.2013.582

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Expression of HMGA1 in the invasion and angiogenesis of human gliomas

ZHENG Shuai, XU Hao, LIU Hua-jie, XING Yi, XU Shang-chen, PANG Qi   

  1. Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2013-09-24 Online:2014-02-10 Published:2014-02-10

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Abstract:

Objective   To explore the role played by HMGA1 in the invasion and angiogenesis of glioma. Methods  The expressions of HMGA1, MMP-9 and VEGF-A in 60 glioma specimens with different WHO classification and 27 glioma specimens with different WHO classification were respectively detected with immunohistochemical method and RT-PCR to analyze the correlation between the expressions and the grades of gliomas. Results  Immunohistochemical Results   showed that HMGA1 protein was expressed in 96.7% (58/60) of the malignant gliomas, of which 25% (15/60) was highly expressed (+++), 46.7% (28/60) was moderately expressed (++), and 28.3% (17/60) was lowly or negatively expressed (0-+), and HMGA1 was not expressed in normal brain tissues. Statistic analysis indicated that HMGA1 was significantly correlated to MMP-9 (r=0.508, P=0.000), and VEGF-A (r=0.316, P=0.014). These Results   were confirmed by RT-PCR. Conclusion  HMGA1 expression is positively correlated to MMP-9 and VEGF-A expressions, which suggests that HMGA1 may be an indicator of the malignancy of gliomas.

Key words: High mobility group A1, Tumor angiogenesis, Glioma, Invasiveness

CLC Number: 

  • R34
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