JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Relationship between proinflammatory cytokine gene polymorphisms and diseases of HBV infection

XING Pei-xiang1a,ZOU Ming-jin1a,XING Quan-tai1b，WANG Hong-chun1a,WANG Yun-shan2   

  1. 1. Qilu Hospital of Shandong University， a. Department of Clinical Laboratory, b. Department of Epidemiology； 2. Central Laboratory, Jinan Central Hospital, School of Clinical Medicine, Shandong University
  • Received:2006-11-28 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24
  • Contact: WANG Yun-shan

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Abstract: ObjectiveTo investigate relationships between the single nucleotide polymorphisms(SNPs) of tumor necrosis factor-α(TNFα) or interleukin-6(IL-6)promoter genes and susceptibility to patients with chronic hepatitis B (HB)in Jinan area. MethodsThe SNPs of the TNF-α(-238G/A and -308G/A) and IL-6(-597G/A, -174G/C and -572G/C) were determined by gene chips in 150 patients infected with hepatitis B virus(HBV) and 100 unrelated healthy controls of selflimited HBV infection. ResultFrequencies of TNF-α-308GG genotype and G allele in patients with HBV infection were significantly higher than those in healthy controls（P＜0.01，OR=6.71， and P＜0.01，OR=2.22， respectively）. TNF-308AA genotype had a cooperative effect on the antiviral therapy （P＜0.05，OR=2.91）. No association was found between any of the other polymorphisms and patients with HBV infection. Conclusion TNF-α-308GG genotype and G allele are significantly related to patients with HBV infection, and TNF-308AA genotype is associated with the response to antiviral therapy.

Key words: Hepatitis B virus, Cytokine, Polymorphism, single nucleotide, Gene chip

CLC Number: 

  • R394
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