JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of KAI1/CD82 and ECadherin expression in epithelialovarian carcinoma

HAN Qiu-yu,ZHANG Xiang-ning,LI Xiao-cui,CAO Li   

  1. Department of Obstetrics and Gynecology， Qilu Hospital of Shandong University， Jinan 250012, Shandong, China
  • Received:2005-10-29 Revised:1900-01-01 Online:2006-07-24 Published:2006-07-24
  • Contact: HAN Qiu-yu

Abstract: To investigate the relationship between epithelial ovarian carcinoma（EOC）and levels of the tumor metastasis suppressor gene KAI1/CD82 and the adhesion molecule ECadherin（Ecad）. Methods：Immunohistochemistry SP method was used to examine the expression levels of KAI1 and Ecad in 66 specimens of EOC. Results：Of them, 38 showed positive KAI1/CD82 protein (57.58%) and 31 positive Ecad protein（46.97%. The statistical evaluation revealed a close relation among the clinical stage, lymph node metastasis and the expressions of KAI1/CD82 and Ecad（P<0.05）, and an inverse relationship between the histological grade and KAI1/CD82 expression levels(P<0.05), suggesting expressions of KAI1/CD82 and Ecad had great consistency in the same sample. Conclusion：Expressions of KAI1/CD82 and Ecad protein are closely related with the malignant progression and metastasis of EOC, which have important implication for evaluation of the differentiation and tumor progression and prediction of the prognosis in EOC.

Key words: Epithelial ovarian carcinoma, Genes, KAI1, ECadherin, Neoplasm metastasis

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