Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (4): 47-51.doi: 10.6040/j.issn.1671-7554.0.2018.1427

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Association between apolipoprotein E gene polymorphism and cerebral microbleeds in ischemic cerebrovascular patients

SONG Yu, TIAN Shufen   

  1. Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China
  • Published:2022-09-27

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Abstract: Objective To investigate the association between apolipoprotein E genotype(ApoE)and cerebral microbleeds(CMBs)in ischemic cerebrovascular. Methods A total of 130 ischemic cerebrovascular patients treated in our hospital during Nov. 2016 and Nov. 2018 were randomly selected and divided into the CMBs group and non-CMBs group according to the results of susceptibility-weighted imaging(SWI). Clinical information and related laboratory tests were collected. The genotypes of ApoE were determined with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Results There were statistical differences in the frequency distributions of ApoE genotypes and alleles between the CMBs group and non-CMBs group (P<0.05). Logistic regression analysis showed that ApoE ε4 carrier (OR: 3.628, 95%CI 1.214~10.839), male (OR: 3.287, 95%CI 1.209~8.934) and carotid atherosclerosis (OR: 4.401, 95%CI 1.614~12.005) were the independent risk factors for CMBs. ApoE ε4 carriers had higher possibility of developing lobar CMBs. Conclusion Apolipoprotein E gene polymorphism is associated with cerebral microbleeds in ischemic cerebrovascular. ApoE ε4 carriers are more likely to develop CMBs than non-carriers.

Key words: Apolipoprotein E, Polymorphism, Cerebral microbleeds, Ischemic cerebrovascular, Susceptibility-weighted imaging

CLC Number: 

  • R743
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