Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (2): 110-116.doi: 10.6040/j.issn.1671-7554.0.2018.1426

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Association of catechol-O-methyl transferase gene G1947A polymorphism with smoking behavior: a Meta-analysis

YIN Xiaolin1, YANG Xiaorong2, ZHANG Tongchao1, MAN Jinyu1, LÜ Ming1,2   

  1. 1. Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Clinical Epidemiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the relationship between catechol-O-methyl transferase(COMT)gene G1947A polymorphism and smoking behavior. Methods Relevant literature were searched in PubMed, EMBASE, Web of Science and Cochrane Library from inception up to Nov. 2018. Data were strictly screened according to the inclusion and exclusion criteria. The combined effect values and the 95% confidence intervals (CI) were calculated based on Meta-analysis. The differences in gender and ethnicity were investigated with subgroup analysis. Results A total of 16 researches were included, with 7 565 current smokers, 6 491 ex-smokers, 9 370 never smokers, 14 535 ever smokers and 16 140 nonsmokers involved. Significant effects of smoking initiation with COMT G1947A polymorphism were found in the dominant model(OR=0.92, 95%CI=0.85-0.98, P=0.014), especially in Asians(OR=0.77, 95%CI=0.62-0.93, P=0.025). The associations of COMT G1947A polymorphism with smoking persistence and cessation were not significant in the 3 models. After sensitivity and influence analyses, the pooled results did not change substantially. No publication bias was detected. Conclusion The A allele in COMT G1947A has a modest protective effect for smoking initiation.

Key words: Smoking behavior, Catechol-O-methyl transferase, Gene, Polymorphism, Meta-analysis

CLC Number: 

  • R18
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