Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (7): 48-55.doi: 10.6040/j.issn.1671-7554.0.2022.0263

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Research progress of animal models of adenomyosis

WANG Guoyun, PAN Zangyu   

  1. Department of Gynecology, Shandong provincial Hospital;
    Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong, China
  • Published:2022-07-27

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Abstract: Adenomyosis refers to the pathological changes caused by the invasion of endometrium (including glands and stroma) into the myometrium. The main clinical symptoms include menorrhagia, severe dysmenorrhea and infertility, which have a serious impact on the physical and mental health of patients. Adenomyosis often occurs in women of childbearing age, but its etiology remains unclear. There is still no specific diagnostic method, and the treatment methods are limited. Researches on the pathogenesis, characteristic diagnosis and targeted treatment are urgently needed. The establishment and application of animal models are significant to solve the above problems since many studies have shown that adenomyosis is not unique to humans. The alternative experimental animals have reproductive system similar to that of human women, which is conducive to the study of mechanism. This paper reviews the establishment and application of animal model of adenomyosis.

CLC Number: 

  • R711.74
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