Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (5): 52-57.doi: 10.6040/j.issn.1671-7554.0.2017.1137

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Effects of stigma maydis polysaccharides on liver protection and glycometabolism in diabetic mice

ZHANG Zhongyi1, ZHANG Qi1, JIE Yi1, ZHOU Si1, WU Haiyan1, ZANG Ying2, PAN Jingxue3, WU Yuping3, NA Xiaodong4   

  1. 1. Department of Clinical Medicine;
    2. Department of Physiology;
    3. Functional Laboratory of Experimental Center for Basic Medical Teaching;
    4. Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong, China
  • Received:2017-11-13 Published:2022-09-27

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Abstract: Objective To investigate the effects of stigma maydis polysaccharides on glycometabolism and liver protection in diabetic mice. Methods Fifty mice were divided into normal control group(NC group), hyperglycemia control group(HG group), metformin group(MET group), 25 mg/kg polysaccharide derived from stigma maydis group(SMP25 group), and 50 mg/kg polysaccharide derived from stigma maydis group(SMP50 group), ten in each group. The diabetic mice models were prepared by peritoneal injection of alloxan, the fasting plasma glucose(FPG)were measured by a blood glucose tester, the content of liver glycogen in mice were measured by colorimetry, and the liver injury was evaluated by drug-induced liver injury-pathological scroring system(DILI-PSS). Results Compared with 山 东 大 学 学 报 (医 学 版)56卷5期 -张众一,等.玉米须多糖对糖尿病小鼠肝损伤及糖代谢的影响 \=-HG group, FPG value was reduced by 34.3%(P<0.001), the content of glycogen was increased by 321.5% in SMP50 group; compared with MET group, the contents of glycogen were increased(P<0.001), and hepatocyte edema and hepatic steatosis were reduced(P<0.001)in SMP25 and SMP50 groups; the effects of blood sugar control and liver protection in SMP50 group is better than those in SMP25 group(P<0.001). Conclusion Polysaccharides derived from stigma maydis can significantly reduce the FPG concentration, promote the synthesis of glycogen, reduce the liver injury caused by modeling drugs and hyperglycemia in diabetic mice, and is expected to provide a effective adjuvant treatment option for diabetics.

Key words: Polysaccharide derived from stigma maydis, Diabetes, Glycogen, Liver injury

CLC Number: 

  • TS201.1
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