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山东大学学报 (医学版) ›› 2022, Vol. 60 ›› Issue (9): 35-41.doi: 10.6040/j.issn.1671-7554.0.2022.0973

• 生育力保护专题 • 上一篇    下一篇

子宫内膜癌、子宫内膜非典型增生保留生育功能后助孕策略

鹿群1,赵璐璐2   

  1. 1.首都医科大学附属北京朝阳医院生殖中心, 北京 100020;2.北京积水潭医院妇产科, 北京 100035
  • 发布日期:2022-09-02
  • 通讯作者: 鹿群. E-mail:luqun1023@sina.com
  • 基金资助:
    国家自然科学基金(82071715);国家重点研发计划项目(2019YFC1005200,2019YFC1005203)

Progress on assisted reproductive technology for women with atypical endometrial hyperplasia and endometrial carcinoma receiving fertilitysparing treatment

LU Qun1, ZHAO Lulu2   

  1. 1. Medical Center for Human Reproduction, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;
    2. Department of Obstetrics and Gynecology, Beijing Jishuitan Hospital, Beijing 100035, China
  • Published:2022-09-02

摘要: 子宫内膜癌及子宫内膜非典型增生的发病率逐渐升高,呈年轻化趋势,且保留生育功能的需求增加。以高效孕激素为基础的子宫内膜癌和子宫内膜非典型增生保留生育功能治疗方法能达到高的完全缓解率,但是生育力依然低下。以“妊娠为目的”积极助孕策略受到学者重视,但是关于子宫内膜癌和子宫内膜非典型增生保留生育功能后助孕缺乏系统研究。本文就保留生育功能治疗后助孕时机、助孕方案以及助孕中的难点进行探究。

关键词: 子宫内膜癌, 保留生育功能, 助孕策略, 来曲唑, 左炔诺孕酮宫内节育系统

Abstract: As the incidences of endometrial carcinoma(EC)and atypical endometrial hyperplasia(AEH)are rising and patients tend to be younger, the demand for fertility preservation is also increasing. Although fertility-preserving therapy based on high-dose progesterone has achieved high rate of complete response(CR), fertility remains low. Pregnancy for women with EC/AEH has attracted attention, but there is a lack of systematic research for increasing pregnancy after fertility-sparing treatment for women with EC and AEH. The paper focuses on the optimal time of initiating in vitro fertilization and embryo transfer(IVF-ET), appropriate ovarian stimulation protocol in women after fertility-sparing treatment for EC and AEH and the difficulties during IVF-ET.

Key words: Endometrial cancer, Fertility preservation, Pregnancy assistance strategies, Letrozole, Levonorgestrel-releasing intrauterine devices

中图分类号: 

  • R711.6
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