Table of Content

  

10 February 2022
Volume 60 Issue 2

Pay attention to sleep problems and prevent self-harm among adolescents

JIA Cunxian, LIU Zhenzhen

Journal of Shandong University (Health Sciences). 2022, 60(2):  1-7.  doi:10.6040/j.issn.1671-7554.0.2021.0164

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As an important risk factor of suicide death and a major public health concern, self-harm is prevalent among adolescents. Identifying risk factors is crucial for developing effective programs to prevent self-harm and suicide in adolescents. Growing evidence demonstrates that sleep problems are potential targets for self-harm with strong operability in screening and intervention. This study reviews the self-harm and sleep problems in adolescents and the correlation between them, aiming to provide a reference for formulating intervention strategies.

Influencing factors and preventive measures of elderly suicide from the perspective of Healthy China Initiative

SU Yonggang, WANG Rui, YANG Tongwei

Journal of Shandong University (Health Sciences). 2022, 60(2):  8-13.  doi:10.6040/j.issn.1671-7554.0.2021.0136

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Implementing the Healthy China Initiative and healthy aging is necessary to deal with population aging. With the rapid increase of aging population, the problem of suicide among the elderly is becoming more serious. The suicide rate of elderly is higher than that of other age groups, and increases with age. The rate of suicide is higher in rural areas than in urban areas, and higher in male than in female. Moreover, the suicidal intention for older adults is strong and suicidal method is lethal. The influencing factors of elderly suicide include physical, psychological and social factors. As suicide is the result of interaction between individual and social factors, prevention and intervention can be carried out from three levels: individual, community, and society.

Protective effect of taurine on cognitive deficit induced by 1-bromopropane

ZHAO Huiwen, XU Lin, SHAN Shan, ZHAO Xiulan

Journal of Shandong University (Health Sciences). 2022, 60(2):  14-21.  doi:10.6040/j.issn.1671-7554.0.2021.1290

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Objective To explore the protective effect of taurine on cognitive deficit induced by 1-bromopropane(1-BP). Methods A total of 60 SPF adult male Wistar rats were randomly divided into control group, 1-BP group, low-dose taurine intervention group, high-dose taurine intervention group and taurine control group according to body weight. 1-BP was dissolved in corn oil and orally administrated at the dose of 800 mg/kg.bw. The spatial learning and memory function of rats were detected with Morris water maze(MWM)15-20 days after the administration of 1-BP. On Day 21, the rats were sacrificed and the cerebral cortex and hippocampus were separated immediately. The content of taurine was determined with high-performance liquid chromatography(HPLC). The expressions of oxidative phosphorylation protein complex of mitochondria and apoptosis related proteins in brains were detected with Western blotting. Results Morris water maze showed that compared with the control group, 1-BP group had longer escape latency, and decreased frequencies of crossing platform(P<0.01); compared with 1-BP group, the low-dose and high-dose taurine intervention groups had shorter escape latency and increased frequencies of crossing platform(P<0.01). The HPLC results showed that compared with the control group, the 1-BP group had significantly decreased taurine contents in cerebral cortex and hippocampus(P<0.001, P<0.05); compared with 1-BP group, the low-dose and high-dose taurine intervention groups had significantly increased taurine level(P<0.001, P<0.01). Compared with the control group, the 1-BP group had significantly decreased expression of mitochondrial oxidative phosphorylation protein complex(OXPHOS)and Bcl-2(P<0.01, P<0.05), but significantly increased expressions of BAX and cleaved capase-3(P<0.05, P<0.01). The alteration trends of OXPHOS and apoptosis related proteins in low-dose and high-dose taurine intervention groups were significantly reversed(P<0.01, P<0.05, P<0.001). Conclusion Taurine supplementation could inhibit neuronal apoptosis, maintain the normal function of mitochondria, and improve the learning and memory dysfunction caused by 1-BP.

Expression of fatty acid transport protein 1 in granulosa cells of patients with polycystic ovary syndrome

SONG Tian, FU Linlin, WANG Qiumin, YANG Xiao, WANG Ying, BIAN Yuehong, SHI Yuhua

Journal of Shandong University (Health Sciences). 2022, 60(2):  22-26.  doi:10.6040/j.issn.1671-7554.0.2021.1148

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Objective To investigate the expression of fatty acid transport protein 1(FATP1)in granulosa cells of patients with polycystic ovary syndrome(PCOS)and its clinical significance. Methods A total of 75 PCOS patients(PCOS group)undergoing in vitro fertilization-embryo transform(IVF-ET)were selected. According to the standard of body mass index(BMI)≥ 25 as obesity, the subjects were divided into normal BMI PCOS group(n=36)and obese PCOS group(n=39). Another 62 patients(control group)seeking assisted reproduction treatment due to tubal or male factors were divided into normal BMI control group(n=31)and obese control group(n=31). The expression of FATP1 in patients granulosa cells was detected with reverse transcription real-time quantitative PCR(qRT-PCR), and its differential expression in PCOS patients was analyzed. Results The expression of FATP1 was higher in PCOS group than in controls(P<0.001), higher in the normal BMI PCOS group than in normal BMI control group(P<0.001), and higher in obese PCOS group than in obese control group(P<0.001). Binary Logistic regression analysis showed that higher FATP1 level(OR=4.242, 95%CI: 2.025-8.883, P<0.001), higher anti-Mullerian hormone level(AMH, OR=1.512, 95%CI: 1.186-1.928, P<0.001), higher luteotropic hormone/follicle stimulating hormone ratio(LH/FSH, OR=4.401, 95%CI: 1.265-15.304, P=0.02), and higher testosterone level(T, OR=1.059, 95%CI: 1.003-1.117, P=0.038)were risk factors of PCOS. Conclusion The expression of FATP1 is increased in PCOS patients, suggesting that FATP1 may play an important role in the development of PCOS.

Expression and significance of poly(ADP-ribose) polymerase-1 in endometriosis

LIN Xueyan, ZHANG Cancan, TIAN Minle, TIAN Yongjie

Journal of Shandong University (Health Sciences). 2022, 60(2):  27-31.  doi:10.6040/j.issn.1671-7554.0.2021.1307

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Objective To detect the expression of poly(ADP-ribose)polymerase-1(PARP-1)in eutopic and ectopic endometria of women with endometriosis, and to explore the correlation among PARP-1, E-cadherin, vimentin and Snail in eutopic and ectopic endometria of women with endometriosis. Methods The expressions of PARP-1, E-cadherin, Vimentin and Snail were detected with immunohistochemistry in eutopic and ectopic endometria of women with endometriosis, and in eutopic endometria of women without endometriosis. The correlation among their expressions was determined with Spearman analysis. Results The expressions of PARP-1, vimentin and Snail significantly increased in eutopic and ectopic endometria of women with endometriosis than in endometria of women without endometriosis(P<0.001), while the expression of E-cadherin significantly decreased(P<0.001). In eutopic endometria of endometriosis, the expression of PARP-1 was negatively correlated with E-cadherin(r=-0.39), but positively correlated with the expressions of vimentin and Snail(r=0.45 and 0.44, respectively); in ectopic endometria of endometriosis, the expression of PARP-1 was negatively correlated with E-cadherin(r=-0.41), but positively correlated with the expressions of vimentin and Snail(r=0.48 and 0.56, respectively). Conclusion PARP-1 is highly expressed in eutopic and ectopic endometria of women with endometriosis, PARP-1 may be involved in the epithelial mesenchymal transformation of endometriosis.

Genetic testing and prenatal diagnosis for a pedigree affected with ATP7B gene variation in Wilson disease

WANG Jing, LIU Xiaozhuan, XU Fangfang

Journal of Shandong University (Health Sciences). 2022, 60(2):  32-36.  doi:10.6040/j.issn.1671-7554.0.2021.0721

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Objective Genetic testing and prenatal diagnosis were used to identify the pathogenic gene variation of Wilson disease in a family. Methods Whole exon sequencing was used to analyze the proband with hepatolenticular degeneration in the family and Sanger sequencing was used to identify the suspected pathogenic variation screened by the proband and his parents. Amniocentesis was performed on the second fetus for prenatal genetic diagnosis. Results It was found that the proband had complex heterozygous variation of ATP7B gene. The missense variation was named NM_000053.3:c.2333G>T(p.Arg778Leu)from his father and the deletion variation was named NM_000053.3:c.208delC(p.Gln70Ser fs*4)from his mother. The missense variation c.2333G>T had been reported and the deletion variation c.208delC had been not reported. The proband's mother underwent prenatal genetic diagnosis at 20 weeks of pregnancy. It was found that the fetus only carried the c.208delC deletion variation from the mother and the c.2333 locus was wild type. The fetus and the proband had different genotypes which predicted that the fetus would not have the same clinical manifestations of hepatolenticular degeneration as the proband. Conclusion The abnormal clinical phenotype of the Wilson disease proband is caused by the complex heterozygous variation of ATP7B gene. It provides the basis for the genetic counseling and prenatal diagnosis for parents who will give birth to a second child.

Clinical and imaging features of adrenal cavernous hemangioma

SONG Yufeng, NING Hao, YAO Zhigang, WU Haihu, LIU Feifan, LYU Jiaju

Journal of Shandong University (Health Sciences). 2022, 60(2):  37-42.  doi:10.6040/j.issn.1671-7554.0.2021.1374

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Objective To analyze the clinical and imaging data of adrenal cavernous hemangioma(ACH), and to summarize the characteristics, diagnosis and treatment experience of the disease. Methods The clinical and imaging data of 6 cases of ACH confirmed by postoperative pathology during Jan. 2011 and Jul. 2021 were retrospectively analyzed, and relevant literatures were reviewed. Results The average age of the patients was 56.8 years(33-69 years). Adrenal tumor was detected in 4 cases during physical examination, and in 2 cases due to hypertension or abdominal discomfort. Blood pressure increased in 4 cases, 2 of which had a history of paroxysmal blood pressure fluctuation. Preoperative MRI enhanced scan was performed in 1 case, which was then diagnosed as hemangioma, and the other preoperative diagnoses included pheochromocytoma(n=2), cyst(n=2)and adenoma(n=1). The average maximum diameter of tumor was 4.2 cm(2.0-7.1 cm). All patients underwent laparoscopic unilateral adrenalectomy. During the median follow-up of 13.5 months(4-130 months), no tumor recurrence was observed, and the 2 patients with a history of paroxysmal blood pressure fluctuation had significant remission. Conclusion ACH is a rare benign adrenal tumor with hidden clinical symptoms, and some patients may have abdominal discomfort and paroxysmal blood pressure fluctuation. The imaging characteristic is delayed inhomogeneous centripetal enhancement, and plain scan with point calcification and edge nodular enhancement can assist the diagnosis. Large-volume ACH needs to be differentiated from pheochromocytoma. The filling speed of contrast medium in enhanced scanning can be used as an important identification point. The combination of CT and MRI can improve the diagnostic accuracy. Laparoscopic surgery is the preferred treatment.

Correlation of helicobacter pylori infection and hypertension in the 2,809 physical examination participants

LYU Yanhong, ZHANG Zhimian

Journal of Shandong University (Health Sciences). 2022, 60(2):  43-47.  doi:10.6040/j.issn.1671-7554.0.2021.1232

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Objective To explore the association between helicobacter pylori (Hp)infection and hypertension in the physical examination population, in order to provide a theoretical basis for the prevention and treatment of hypertension. Methods This cross-sectional study involved 2,809 participants who underwent ¹³C-urea breath test, blood pressure and fasting blood examination during January 2021 and June 2021. The participants were divided into hypertensive group(n=485)and non-hypertensive group(n=2 324)according to the examination results. The incidence of Hp infection was compared between two groups. The correlation of Hp infection with systolic pressure, diastolic pressure, mean arterial pressure, and pulse pressure was analyzed with multiple linear regression. The risk factors for hypertension were analyzed with multivariate Logistic regression. Results The incidence of Hp infection was significantly higher in the hypertensive group than in the non-hypertensive group(P<0.001). Multiple linear regression showed that Hp infection was positively associated with diastolic pressure(β=0.862, 95%CI: 0.019-1.706, P=0.045)and mean arterial pressure(β=0.975, 95%CI: 0.074-1.876, P=0.034). Multivariate Logistic regression showed that Hp infection was an independent risk factor for hypertension(OR=1.667, 95%CI: 1.324-2.099, P<0.001). Conclusion Hp infection is closely associated with diastolic blood pressure and mean arterial pressure, which can significantly increase the risk of hypertension, suggesting that active control of Hp infection is beneficial to preventing or reducing the incidence of hypertension.

GnRHa in combination with rhGH in the treatment of an infantile hypothalamic hamartoma and literature review

WANG Zengmin, HAN Jinyan, LI Guimei

Journal of Shandong University (Health Sciences). 2022, 60(2):  48-53.  doi:10.6040/j.issn.1671-7554.0.2021.1365

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Objective To investigate the treatment strategy and outcome of central precocious puberty(CPP)secondary to hypothalamic hamartoma(HH)in children. Methods The clinical data of a girl with HH presenting with vaginal bleeding and breast development were retrospectively analyzed. The word “hypothalamic hamartoma” was used as a keyword to retrieve literature. Results The female patient presented with intermittent vaginal bleeding and breast development at the age of 4 months after birth aged 3 years and 11 months at the time of diagnosis, and was diagnosed as “central precocity and grey nodular hamartoma.” After 1-year treatment with gonadotropin-releasing hormone analogs(GnRHa), her height did not increase as desired and the prediction was that her height would be impaired when she grew up. After that, recombinant human growth hormone(rhGH)was added, and the combination therapy was terminated after 3.5 years when the girl was 8.5 years old. Regular menstruation resumed 1 year after medications withdrawal. At the age of 10 years and 7 months, her height reached 164.8 cm, higher than the target height. Reexamination showed that sex hormones were normal and no adverse reactions were observed. MRI of pituitary gland showed no changes in tumor size and location. Conclusion CPP secondary to HH can occur in infancy, which needs to be differentiated from mini-puberty. GnRHa is recommended; combination treatment with rhGH should be administered when the patients’ height may be affected, which is not only safe, but highly effective.

Mitochondrial myopathy beginning with respiratory failure: one case and literature review

PAN Pengfei, XU Lisheng, JI Kunqian, WANG Dexiang, LI Yu

Journal of Shandong University (Health Sciences). 2022, 60(2):  54-59.  doi:10.6040/j.issn.1671-7554.0.2021.1195

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Objective To analyze the clinical characteristics, diagnosis, and treatment strategies of patients with mitochondrial myopathy beginning with respiratory failure. Methods A case of mitochondrial myopathy beginning with respiratory failure was analyzed, previous case reports were retrieved, and the literature was reviewed. Results Twelve patients onset of type Ⅱ respiratory failure were retrieved, of which seven were males and five were females, with the age of onset ranging from 16 to 70 years old. Eight patients had elevated lactic acid, and four patients had elevated creatine kinase. One-third of the patients have normal electromyogram. The A3243G mutation in mitochondrial DNA was detected in 50% of patients. Mitochondrial myopathy could be diagnosed by combining the patients clinical manifestations and muscle biopsy pathology. There was currently no specific treatment. Conclusion In clinical type Ⅱ respiratory failure of unknown cause, the possibility of mitochondrial myopathy needs to be considered.

A case of infective endocarditis and acute kidney injury with positive PR3-ANCA

WANG Zhouyang, JIANG Bei, LI Xianhua, ZHEN Junhui, YANG Xiangdong, HU Zhao, LIU Guangyi, PEI Fei

Journal of Shandong University (Health Sciences). 2022, 60(2):  60-64.  doi:10.6040/j.issn.1671-7554.0.2021.0836

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Objective To explore the clinical characteristics of infective endocarditis and acute kidney injury with positive PR3-ANCA, so as to improve the understanding of this disease, reduce misdiagnosis, and provide clues for treatment. Methods A case of acute kidney injury admitted to Qilu Hospital of Shandong University on February 18, 2017 was reported. Infectious endocarditis with neoplasms and positive PR3-ANCA were detected during echocardiography. Clinical manifestations, laboratory examination, treatment, follow-up and prognosis were analyzed. Results The patients renal function recovered well after cardiac surgery combined with aggressive anti-infective therapy. Conclusion Anti-infective treatment is the most basic treatment for kidney injury caused by infective endocarditis. For ANCA positive young patients with fever, acute renal injury with hematuria, proteinuria and decreased complements, the possibility of vasculitis as well as infective endocarditis should be considered.

Clinical analysis of 32 cases of ingested super absorbent polymer balls in children

XUE Ning, GUO Qingwei

Journal of Shandong University (Health Sciences). 2022, 60(2):  65-68.  doi:10.6040/j.issn.1671-7554.0.2021.0644

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Objective To summarize the characteristics and prognosis of ingested super absorbent polymer balls in children, thus to provide basis and guidance for future clinical treatment. Methods The clinical data of 32 cases of ingested super absorbent polymer balls in children in Qilu Childrens Hospital of Shandong University were retrospectively analyzed, including age, gender, time of swallowing, location of foreign body, imaging examination, digestive endoscopy, treatment, complication and prognosis. Results A total of 32 cases of ingested super absorbent polymer in children were collected, including 18 males and 14 females, mean age was(2.75±1.55)years, median time of swallowing was 5.00(3.25, 13.50)h. Foreign bodies were mainly lodged in the small intestine and the stomach. Clinical symptoms and complications were found in 7 patients(21.88%). Symptoms included vomiting, abdominal distension, abdominal pain, crying, and refusal to eat; complications were mainly intestinal obstruction and electrolyte disturbance. Totally 20 cases(62.50%)discharged automatically, 5 cases(15.63%)by gastroscope, and 7 cases(21.88%)by surgery operation. All cases had good prognosis and no deaths occurred. The occurance rate of complications in the group with swallowing time < 12 hours had no statistical difference with the group with swallowing time ≥12 hours(P=0.327). Conclusion Super absorbent polymer balls is harmful to children. Early diagnosis and intervention is helpful to reduce the occurrance of complications. More precautious measures should be taken for children.

Research progress of suicide warning systems for adolescents and young adults

XU Xiaoming, KONG Yiting, LIU Chuan, MING Ying, KUANG Li

Journal of Shandong University (Health Sciences). 2022, 60(2):  69-74.  doi:10.6040/j.issn.1671-7554.0.2021.0379

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Suicide is one of the leading causes of death among adolescents and young adults and brings a heavy burden of disease to families and society. The World Health Organization identifies suicide as a serious public health event and calls on member countries to establish a nationwide strategy of suicide prevention to reduce the global suicide rate by one-third by 2030. This article analyzed the studies on the progress of suicide early warning systems for adolescents and young adults in countries around the world from 2000 to 2020 in four aspects: the screening of suicide risk factors, the tools of suicide screening, screening process, and the effectiveness of suicide screening. This review aimed to provide a reference for professionals on adolescents suicide in schools, communities, and hospitals and provided ideas for establishing a national strategy of suicide prevention in China.

Revision, reliability and validity test of the Gerontological Service Career Motivation Scale among undergraduates in graduation year

YE Yi, ZHANG Jie, ZHAO Qiuge, FAN Xiuzhen

Journal of Shandong University (Health Sciences). 2022, 60(2):  75-80.  doi:10.6040/j.issn.1671-7554.0.2021.0773

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Objective To revise the Gerontological Service Career Motivation Scale and examine its psychological measurement characteristics. Methods The Gerontological Service Career Motivation Scale was revised. Its reliability and validity were measured in 544 undergraduates majoring in gerontological services, and the Career Adaptabilities Scale-China Form was selected as the criterion-related validity instrument. Results After 3 items whose correlation coefficient was less than 0.4 were deleted, 17 items were retained. Career expectation and career value were extracted from exploratory factor analysis, which accounted for 63.85% of the total variance. The results of confirmatory factor analysis showed that the total scale and subscales fitted well with the structure model. The total scores were positively correlated with the scores of career adaptability(r=0.72, P<0.001). Reliability analysis showed that Cronbachs α coefficients of career expectation and career value ranged from 0.92 to 0.96, and the test-retest reliabilities ranged from 0.70 to 0.84. Conclusion The Gerontological Service Career Motivation Scale has good validity and reliability, which can be used to measure the undergraduates motivation to choose gerontological service as a career.

Spatio-temporal distribution of stroke in Zibo City in 2019 based on township scale

FANG Qidi, YANG Shuxia, QI Chang, CHENG Chuanlong, HAN Chuang, LIU Ying,CUI Feng, LI Xiujun

Journal of Shandong University (Health Sciences). 2022, 60(2):  81-88.  doi:10.6040/j.issn.1671-7554.0.2021.0758

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Objective To explore the spatio-temporal distribution characteristics of stroke in various towns(subdistricts)in Zibo City in 2019, so as to provide references for the preventive and control strategies. Methods The data of stroke cases in Zibo City in 2019 were collected. The spatial autocorrelation analysis, circular distribution method and scan statistics were used to explore the spatio-temporal distribution characteristics of stroke. Results The total number of stroke cases was 18,469, with a crude incidence rate of 407.65/100,000. The crude incidence rate of men(464.90/100,000)was higher than that of women(350.03/100,000), and showed an increasing trend with the increase of age. The main type of disease was ischemic stroke(84.06%). In terms of space, cases were mainly distributed in Yiyuan County, Zhangdian District and Zichuan District. In terms of time, cases mainly occurred from January to early May and from the end of August to November. Conclusion The distribution of stroke cases is different in space and time. Various disease prevention and control departments can strengthen the prevention and intervention of stroke according to local conditions, so as to effectively reduce the incidence of stroke.

Effects of ambient temperature and relative humidity on rotavirus diarrhea among children under 5 years old in Shenzhen City during 2014-2016

HAO Qiang, GAO Qi, ZHAO Ran, WANG Haitao, LIU Zhidong, JIANG Baofa

Journal of Shandong University (Health Sciences). 2022, 60(2):  89-95.  doi:10.6040/j.issn.1671-7554.0.2021.0820

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Objective To investigate the non-linear and lag effects of meteorological factors on rotavirus diarrhea in children under 5 years old in Shenzhen. Methods The correlation between meteorological factors and rotavirus diarrhea in Shenzhen from 2014 to 2016 was analyzed. The effects of temperature and relative humidity on rotavirus diarrhea were analyzed using distributed lag non-linear model(DLNM)after controlling for confounding factors including other meteorological variables and long-term trend. Results Low temperature was a risk factor for rotavirus diarrhea. The strongest effects of 5th(13.4 ℃)(RR=1.118, 95%CI: 1.096-1.139)and 25th(19 ℃)(RR=1.076, 95%CI: 1.063-1.090)percentiles of temperature occurred at the lag-11 day. The cumulative effects at the lag-21 day were 6.828(95%CI: 5.059-9.215)and 3.244(95%CI: 2.641-3.985). There were no statistically significant differences at P₇₅(28.2 ℃)and P₉₅(30.1 ℃). Relative humidity was associated with a decreased risk of rotavirus diarrhea. When relative humidity was P₅(52.75%), there were adverse effects from the lag day 2 to lag day 16, the strongest lag effect occurred at the lag day 4(RR=1.063, 95%CI: 1.040-1.085), and the lag-21 day cumulative RR was 1.565(95%CI: 1.205-2.032). When the relative humidity was P₇₅(83%)or P₉₅(91%), it had significant protective impacts on rotavirus diarrhea, and the cumulative RR were 0.720(95%CI: 0.663-0.782)and 0.283(95%CI: 0.224-0.358), respectively. Conclusion Temperature and relative humidity have a non-linear and lag pattern on rotavirus diarrhea. Low temperature is a risk factor for rotavirus diarrhea, and there is a significant negative correlation between relative humidity and the number of rotavirus cases. We suggest that relevant departments should strengthen health education for children under 5 years old in the low temperature and low humidity season, and take timely protective measures to prevent the epidemic of rotavirus.

Comparison of prediction effects of DLNM and LSTM neural network on the incidence of hand, foot and mouth disease in Linyi City

FENG Yiping, SUN Dapeng, WANG Xianjun, JI Yiman, LIU Yunxia

Journal of Shandong University (Health Sciences). 2022, 60(2):  96-101.  doi:10.6040/j.issn.1671-7554.0.2021.0707

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Objective To analyze and predict the incidence trend of hand, foot and mouth disease(HFMD)in Linyi City, Shandang Province by using the distributed lag non-linear model(DLNM)and long-short term memory(LSTM)neural network, and to provide reference for effective prevention and control of the disease. Methods The daily incidence data from Jan. 1, 2011 to Dec. 31, 2015 were collected to establish the DLNM and LSTM neural network, respectively. The daily incidence data from Jan. 1, 2016 to Dec. 31, 2017 were used to test and compare the prediction effects of the two models. Results A total of 25,999 HFMD cases were reported during Jan. 1, 2011 to Dec. 31, 2017. The root mean square error(RMSE)of DLNM and LSTM neural network extrapolation prediction from Jan. 1, 2016 to Dec. 31, 2017 were 11.93 and 5.74, respectively, and the mean absolute deviation(MAE)were 7.93 and 3.60, respectively, indicating the prediction accuracy of LSTM was better than that of DLNM, and the prediction results were basically consistent with the actual situation. Conclusion LSTM neural network has a good fitting and prediction effect on the incidence trend of HFMD in Linyi City, which can provide guidance for the prediction and warning of the disease.

Epidemiological characteristics and influencing factors of malignant tumors in Zibo, 2018

CHENG Chuanlong, YANG Shuxia, SHE Kaili, FANG Qidi, HAN Chuang, LIU Ying, CUI Feng, LI Xiujun

Journal of Shandong University (Health Sciences). 2022, 60(2):  102-108.  doi:10.6040/j.issn.1671-7554.0.2021.0672

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Objective To explore the epidemiological characteristics of malignant tumors in Zibo City, Shandong Province, and to analyze the correlation between the incidence and influencing factors, so as to provide a scientific basis for the prevention and control of malignant tumors and the formulation of relevant policies. Methods Based on the incidence data of malignant tumors in Zibo City in 2018, global and local aggregation analyses were performed with spatial autocorrelation statistical method to reveal the epidemiological characteristics of malignant tumors. Spearman rank correlation was used to analyze the correlation between the incidence and the influencing factors. Results The number of reported cases of malignant tumors was 17,379 in 2018, and the crude incidence was 383.55/100,000. The high risk group were 55 years and above, mainly working in agriculture, forestry, animal husbandry, fishing and water conservancy. The number of malignant tumor cases in each township of Zibo City had a certain spatial aggregation, especially in Zhangdian District and Huantai County, consistent with the spatial distribution of PM_2.5 high concentration area. Correlation analysis showed that the per capita disposable income was positively correlated with the incidence of malignant tumors(r_s=0.86, P=0.01), and PM_2.5 concentration was highly correlated with the incidence of malignant tumors in high GDP areas(r_s=1.00, P<0.01). Conclusion The number of cases and incidence of malignant tumors are still high in Zibo City, but the distribution area is relatively concentrated, so it is suggested to pay more attention to the key areas. Local environmental governance should be strengthened and early diagnosis and early treatment should be carried out for high risk groups to reduce the fatality rate and disease burden of malignant tumors.

Changing trend and influencing factors of blood pressure level among staff based on panel data model

LUO Xiao, DAI Xiang, JIA Cunxian, SONG Huacui, GAO Lijie

Journal of Shandong University (Health Sciences). 2022, 60(2):  109-114.  doi:10.6040/j.issn.1671-7554.0.2021.0778

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Objective To analyze the changes of blood pressure of staff in an enterprise for 4 consecutive years and to analyze the impact of blood sugar, blood lipids and other health examination indicators on blood pressure using the panel data model. Methods The health examination results from 2015 to 2018 were collected, and panel data were established. The changes in blood pressure were determined with trend test. With systolic and diastolic blood pressure as dependent variables, blood glucose, blood lipids, other health examination indicators as independent variables, and age as control variables, effects of the above indicators on blood pressure were analyzed with fixed-effects model. Results (1) Systolic blood pressure increased over time(F=12.451, P<0.05)and diastolic blood pressure showed a fluctuating upward trend(F=7.682, P<0.05). (2) Multivariate analysis showed that fasting blood glucose, triglyceride, total cholesterol, and low-density lipoprotein were risk factors of systolic blood pressure(P<0.05); fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein, and homocysteine were risk factors of diastolic blood pressure(P<0.05). Conclusion The blood pressure shows an upward trend over time. Due attention should be paid to blood sugar, blood lipids and other indicators to control blood pressure.