Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (2): 60-64.doi: 10.6040/j.issn.1671-7554.0.2021.0836

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A case of infective endocarditis and acute kidney injury with positive PR3-ANCA

WANG Zhouyang1, JIANG Bei1, LI Xianhua1, ZHEN Junhui2, YANG Xiangdong1, HU Zhao1, LIU Guangyi1, PEI Fei1   

  1. 1. Department of Nephrology;
    2. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-01-25

Abstract: Objective To explore the clinical characteristics of infective endocarditis and acute kidney injury with positive PR3-ANCA, so as to improve the understanding of this disease, reduce misdiagnosis, and provide clues for treatment. Methods A case of acute kidney injury admitted to Qilu Hospital of Shandong University on February 18, 2017 was reported. Infectious endocarditis with neoplasms and positive PR3-ANCA were detected during echocardiography. Clinical manifestations, laboratory examination, treatment, follow-up and prognosis were analyzed. Results The patients renal function recovered well after cardiac surgery combined with aggressive anti-infective therapy. Conclusion Anti-infective treatment is the most basic treatment for kidney injury caused by infective endocarditis. For ANCA positive young patients with fever, acute renal injury with hematuria, proteinuria and decreased complements, the possibility of vasculitis as well as infective endocarditis should be considered.

Key words: Acute kidney injury, Infective endocarditis, Anti-neutrophil cytoplasmic antibody, Antibiotics, Glucocorticoid

CLC Number: 

  • R542
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