Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (9): 43-50.doi: 10.6040/j.issn.1671-7554.0.2021.0963

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Advances on drugs derived from microbial sources and future perspectives

JU Jianhua1, YANG Zhenye2,3, LI Qinglian2, HAN Yanan2,3, LI Yanqing2,3, QIAO Yijun2, YANG Hu1, ZHANG Huaran2,3   

  1. 1. School of Pharmaceutical Sciences, Shandong University, Jinan 2500012, Shandong, China;
    2. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, Guangdong, China;
    3. College of Marine Science, University of Chinese Academy of Sciences, Beijing 100049, China
  • Published:2021-10-15

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Abstract: Microbial drugs play important roles in a panel of therapeutic areas, such as anti-infection, anti-cancer, immunosuppression and metabolic disorder. The long-term abuse of antibiotics has led to the emergence and widespread of drug-resistant bacteria, bringing unprecedented challenges worldwide to the safe and healthy development of public health. Therefore, there is an urgent need for research and development of novel antibiotics. How to discover new drugs with novel chemical structure and mechanism of action from microorganisms to combat the increasingly severe bacterial resistance has become a new challenge for the research and development of microbial drugs. In this review, we gave an overview of the history of microbial drug discovery. The number, producer and indication of the microorganism-derived clinic drugs approved by developed countries, between 1940 and 2019 were also summarized. In addition, due to the urgent need for novel microbial drugs, new strategies for microbiological drug research and development were summarized.

Key words: Microbial drugs, Antibiotics, Drug resistance, Strategies for drug research and development

CLC Number: 

  • R574
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