Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (12): 54-59.doi: 10.6040/j.issn.1671-7554.0.2020.0753

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Expression of P-glycoprotein in the colonic mucosa of ulcerative colitis patients and its clinical significance

FU Zhenmei1, MA Mingze2   

  1. 1. Department of Medical Imaging;
    2. Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2020-12-08

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Abstract: Objective To detect the expression of P-glycoprotein(P-GP)in the colonic mucosa of patients with ulcerative colitis(UC)before and after hormonotherapy, explore its correlation with the peripheral endotoxin and D-lactic acid levels, and investigate its association with UC. Methods Previously untreated UC patients(n=102)and healthy controls(n=31)were selected. The expression of P-GP in the colonic mucosa of UC patients before and after treatment, and that of healthy controls were detected with immunohistochemistry. The peripheral endotoxin and D-lactic acid levels were detected with ELISA and ultraviolet spectrophotometry respectively. Results Before hormonotherapy, the peripheral endotoxin ［(0.67±0.58)vs(18.15±0.73), P<0.01］ and D-lactic acid level ［(1.75±1.25)vs(10.85±1.94), P<0.05］ of UC patients were higher than those of healthy controls, while the expression of P-GP was lower(P<0.05). Two months after hormonotherapy, the total positive rate and strong positive rate of UC patients were significantly higher than the rates before therapy(P<0.05). The peripheral endotoxin and D-lactic acid levels before and after hormonotherapy were negatively correlated with P-GP expression. Conclusion The impaired intestinal barrier and increased intestinal permeability in UC patients may be related to the low expression of P-GP in intestinal mucosa. The P-GP expression may be correlated with the pathogenesis of ulcerative colitis.

Key words: Ulcerative colitis, P-glycoprotein, Multidrug resistance gene, Intestinal mucosa barrier

CLC Number: 

  • R574
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