Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (1): 48-54.doi: 10.6040/j.issn.1671-7554.0.2021.0516

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Clinical characteristics and placental pathology of bloodstream infection in 50 pregnant women

LI Yan1, LIU Jing1, LI Juan2, YANG Qiuhong1   

  1. 1. Department of Obstetrics and Gynecology;
    2. Department of Pathology, Jinan Maternity and Child Care Hospital, Jinan 250001, Shandong, China
  • Published:2022-01-08

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Abstract: Objective To analyze the clinical characteristics and placental pathology of bloodstream infection in pregnant women. Methods A total of 50 pregnant women with bloodstream infection during Aug. 1, 2016 and Aug. 1, 2020 were selected as the bloodstream infection group, and another 50 pregnant women without blood stream infection were selected as the control group. The age, delivery mode, infection time, application of special antibiotics, fetal distress, stillbirth, abortion, premature delivery, neonatal infection, septic shock, maternal death, placenta maternal inflammatory reaction, placenta fetal inflammatory reaction and other indicators were analyzed. The pathogenic bacteria isolated from blood culture in the bloodstream infection group were collected, the distribution of pathogenic bacteria was analyzed, and the drug sensitivity results of the pathogenic bacteria with the highest detection rate were analyzed. Results The use of special antibiotics in the bloodstream infection group was higher than that in the control group(P<0.001). The bloodstream infection group had higher probability of septic shock(P=0.041), premature delivery(P=0.007), abortion(P=0.012), stillbirth(P=0.041), neonatal infection(P=0.022), placental maternal inflammation(P=0.006)and placental fetal inflammation(P=0.003)than the control group. The top 6 pathogenic bacteria were Escherichia coli(50%), Listeria(10%), Enterococcus faecalis(8%), Streptococcus pyogenes(6%), Streptococcus agalactiae(4%), Staphylococcus aureus(4%). Escherichia coli was sensitive to cefoxitin, ceftazidime, tobramycin, and ampicillin/sulbactam(≥80%). The sensitivity rates to meropenem, imipenem, amikacin, cefoperazone/sulbactam, piperacillin/tazobactam and ticacillin/clavulanate were over 95%. Conclusion Bloodstream infection seriously threatens the life and health of mothers and children. Escherichia coli has the highest infection rate, and Streptococcus pyogenes and Listeria also have serious harm to mothers and children. For pregnant women with fever, early standardized blood culture and targeted selection of sensitive antibiotics can improve the prognosis and reduce the mortality of mothers and children.

Key words: Bloodstream infection, Pregnancy, Pathogens, Drug resistance, Placental pathology

CLC Number: 

  • R714.7
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