Abstract: Objective To analyze the distribution and antimicrobial resistance of multiple pathogens in males with genital tract infections. Methods Multiple pathogens in clinical specimens collected from 7 hospitals in Taian during Sep. 2016 and Sep. 2018 were cultured. Neisseria gonorrhoeae(NG)was cultured on a chocolate tablet containing vancomycin and identified with mass spectrometry, and drug susceptibility was tested with agar dilution method. Ureaplasma urealyticum(UU)was cultured in broth, and drug susceptibility was tested with broth dilution method. Mycoplasma hominis(MH)was tested with IES. Results A total of 507 positive samples were screened out, among which the infection rate of simple UU, simple NG, and multiple pathogens was 39.84%, 23.08%, and 26.43%, respectively. The resistance rate of NG against ciprofloxacin(CIP), penicillin(PEN), and tetracycline(TET)was 96.90%, 96.27%, and 96.65%, respectively. The rate of decreased susceptibility of NG against ceftriaxone(CRO)and cefixime(CFM)was 9.32% and 9.94%, respectively. The susceptibility rates of UU and MH against minocycline(MIN), doxycycline(DOX)and josamycin(JOS)were more than 90%. Conclusion The infection rate of simple UU ranked the first, followed by simple NG. The third-generation cephalosporins such as CRO and CFM remained the first-line therapy for NG infections, and MIN, DOX and JOS were effective antibiotics for UU and MH infections.

Key words: Male, Urogenital tract, Multiple pathogens, Infection, Antimicrobial resistance, Taian