Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (2): 43-47.doi: 10.6040/j.issn.1671-7554.0.2021.1232

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Correlation of helicobacter pylori infection and hypertension in the 2,809 physical examination participants

LYU Yanhong, ZHANG Zhimian   

  1. Department of Health Management Center, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-01-25

Abstract: Objective To explore the association between helicobacter pylori (Hp)infection and hypertension in the physical examination population, in order to provide a theoretical basis for the prevention and treatment of hypertension. Methods This cross-sectional study involved 2,809 participants who underwent 13C-urea breath test, blood pressure and fasting blood examination during January 2021 and June 2021. The participants were divided into hypertensive group(n=485)and non-hypertensive group(n=2 324)according to the examination results. The incidence of Hp infection was compared between two groups. The correlation of Hp infection with systolic pressure, diastolic pressure, mean arterial pressure, and pulse pressure was analyzed with multiple linear regression. The risk factors for hypertension were analyzed with multivariate Logistic regression. Results The incidence of Hp infection was significantly higher in the hypertensive group than in the non-hypertensive group(P<0.001). Multiple linear regression showed that Hp infection was positively associated with diastolic pressure(β=0.862, 95%CI: 0.019-1.706, P=0.045)and mean arterial pressure(β=0.975, 95%CI: 0.074-1.876, P=0.034). Multivariate Logistic regression showed that Hp infection was an independent risk factor for hypertension(OR=1.667, 95%CI: 1.324-2.099, P<0.001). Conclusion Hp infection is closely associated with diastolic blood pressure and mean arterial pressure, which can significantly increase the risk of hypertension, suggesting that active control of Hp infection is beneficial to preventing or reducing the incidence of hypertension.

Key words: Helicobacter pylori, Infection, Hypertension, Physical examination, Risk factor

CLC Number: 

  • R181.3
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