Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (4): 107-112.doi: 10.6040/j.issn.1671-7554.0.2021.1352

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Prevalence and risk factors of latent tuberculosis infection among nursing staff in some designated hospitals in Shandong Province

LI Yanli1, LI Yan2, SHE Kaili3, LIU Ying3, LIU Weijuan1, LI Xiujun3, LIU Yinghui1   

  1. 1. Department of Nursing, Shandong Public Health Clinical Center, Jinan 250013, Shandong, China;
    2. Department of Infection, Shandong Public Health Clinical Center, Jinan 250013, Shandong, China;
    3. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2022-04-22

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Abstract: Objective To investigate the prevalence and risk factors of latent tuberculosis infection(LTBI)among nursing staff in some designated hospitals in Shandong Province and provide scientific basis for the management of LTBI high-risk groups and reduction of occupational infection. Methods A questionnaire was designed for 631 nurses working in the designated tuberculosis hospitals from January 2018 to December 2019 and a cross-sectional survey was conducted. Results The latent infection rate was 17.43%. Univariate analysis indicated that education level, unit type, working years related to tuberculosis control, family members having history of tuberculosis and working place had statistical significance(P<0.05). Multivariate binary Logistic regression analysis indicated that the risk of tuberculosis infection increased with the increase of working years related to tuberculosis control. With 2-year as a reference, the risk of working for 6-10 years increased by 3.12 times(OR=3.12, 95%CI: 1.21-8.03), and the risk of working for more than 10 years increased by 5.33 times(OR=5.33, 95%CI: 2.17-13.09); if there were TB cases in family, the risk of infection could be 4.10 times higher(OR=4.10, 95%CI: 2.26-7.41). Conclusion The latent infection rate of nurses in some designated hospitals in Shandong Province is close to that of the general population. LTBI risk increases significantly as caregivers increase their years of tuberculosis control and have family members who have a history of tuberculosis. Preventive measures should be givn priority to the occupational exposed group to block the development of active tuberculosis.

Key words: Tuberculosis, Latent tuberculosis infection, Infection control, Interferon-gamma release assay

CLC Number: 

  • R574
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