JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (9): 77-81.doi: 10.6040/j.issn.1671-7554.0.2016.005

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HIV drug resistance and the impact of antiretroviral therapy initiated at different stages among AIDS patiens

YUAN Yuan1, SI Heng1, LIU Hongwei1, LIU Chunhua1, WANG Zhe1, RUAN Yuhua2, XING Hui2   

  1. 1. Institute for AIDS/STD Prevention and Cure, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Hennan, China;
    2. National Center for AIDS/STD Control and Prevention, China CDC, Beijing 102206, China
  • Received:2016-01-04 Online:2016-09-10 Published:2016-09-10

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Abstract: Objective To compare the impact of antiretroviral therapy initiated at different stages on drug resistance among AIDS patients. Methods AIDS patients treated with first-line HAART for 6 months in Henan Province were investigated with cross-sectional survey and blood samples were collected. According to the level of baseline immunology, the patients were divided into 3 groups: early treatment group(n=132, CD4+T cell counts ≥ 350 cell/mm3), conventional treatment group(n=200, 200 cell/mm3 < CD4+T cell counts < 350 cell/mm3)and delayed treatment group(n=329, CD4+T cell counts ≤ 200 cell/mm3). The factors associated with the development of HIV-1 drug resistance were analyzed with multivariate logistic regression. Results A total of 661 patients were investigated. The total prevalence of HIV-1 drug resistance was 34.3%(227/661). The prevalence of drug resistance in the early treatment group, conventional treatment group and delayed treatment group was 21.2%(28/132), 35.5%(71/200)and 38.9%(128/329), respectively. Multivariate logistic regression analysis showed that the protective factors associated with the development of drug resistance included earlier treatment(OR=0.31, 95%CI 0.19-0.51, P<0.001), high compliance(OR=0.48, 95%CI 0.30-0.78, P=0.003)and initiation of ART with 3TC(OR=0.20, 95%CI 0.20- 山 东 大 学 学 报 (医 学 版)54卷9期 -袁源,等.不同时期抗病毒治疗对艾滋病患者耐药产生的影响分析 \=-0.40, P<0.001), while long-duration of treatment(OR=1.90, 95%CI 1.22-2.95, P=0.004 3)was the risk factor. Conclusion Early initiation of antiretroviral therapy for AIDS patients receiving HAART could reduce the emergence of the drug resistant strains and acquire good effect.

Key words: Acquired Immune Deficiency Syndrome, Early initiation of antiretroviral therapy, Influencing factor, Drug resistance

CLC Number: 

  • R183.9
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