Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (9): 51-56.doi: 10.6040/j.issn.1671-7554.0.2021.0961

Previous Articles     Next Articles

Role and regulatory mechanism of type 2 immunity in tissue repair

GE Shaohua, DING Tian, LIU Hongrui   

  1. Department of Periodontology, School and hospital of Stomatology, Shandong University, Jinan 250012, Shandong, China
  • Published:2021-10-15

RichHTML

46

PDF (PC)

1300

Abstract: The repair and regeneration of damaged tissue has always been a research hotspot in regenerative medicine. Traditional regenerative medicine relies on stem cell, growth factor, and scaffold to achieve tissue regeneration, but the safety and effectiveness in the clinic still need to be verified. In recent years, growing evidences have shown that the immune system is crucial in tissue repair and regeneration, which provides a new avenue for regenerative medicine. Type 2 immunity, involved in various immune cell subsets, is characterized by the production of interleukin(IL)-4, IL-5, IL-9, IL-10, IL-13, and IL-33. It plays a key role in regulating the immune environment during tissue repair. This paper reviews the role and regulatory mechanism of type 2 cytokines and individual immune cell subsets in tissue repair and regeneration following injury.

Key words: Type 2 immunity, Tissue repair, Immune cell, Cytokines

CLC Number: 

  • R392
[1] Gieseck RL 3rd, Wilson MS, Wynn TA. Type 2 immunity in tissue repair and fibrosis [J]. Nat Rev Immunol, 2018, 18(1): 62-76.
[2] Eming SA, Wynn TA, Martin P. Inflammation and metabolism in tissue repair and regeneration [J]. Science, 2017, 356(6342): 1026.
[3] Raziyeva K, Kim Y, Zharkinbekov Z, et al. Immunology of acute and chronic wound healing [J]. Biomolecules, 2021, 11(5): 700.
[4] 朱方强, 陈民佳, 朱明, 等. 炎症与组织再生修复 [J]. 中华损伤与修复杂志(电子版), 2017, 12(1): 72-76. ZHU Fangqiang, CHEN Minjia, ZHU Ming, et al. Inflammatory and tissue regeneration, repair [J]. Chinese Journal of Repair and Wound Healing(Electronic Edition), 2017, 12(1): 72-76.
[5] Boucher D, Monteleone M, Coll RC, et al. Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity [J]. J Exp Med, 2018, 215(3): 827-840.
[6] Wynn TA. Type 2 cytokines: mechanisms and therapeutic strategies [J]. Nat Rev Immunol, 2015, 15(5): 271-282.
[7] Otsuka A, Nakajima S, Kubo M, et al. Basophils are required for the induction of Th2 immunity to haptens and peptide antigens [J]. Nat Commun, 2013, 4:1739. doi: 10.1038/ncomms2740.
[8] Goh YP, Henderson NC, Heredia JE, et al. Eosinophils secrete IL-4 to facilitate liver regeneration [J]. Proc Natl Acad Sci U S A, 2013, 110(24): 9914-9919.
[9] Landen NX, Li D, Stahle M. Transition from inflammation to proliferation: a critical step during wound healing [J]. Cell Mol Life Sci, 2016, 73(20): 3861-3885.
[10] Wen T, Rothenberg ME. The regulatory function of eosinophils [J]. Microbiol Spectr, 2016, 4(5): 10.1128/microbiolspec.MCHD-0020-2015. doi: 10.1128/microbiolspec.MCHD-0020-2015.
[11] Turner JE, Morrison PJ, Wilhelm C, et al. IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation [J]. J Exp Med, 2013, 210(13): 2951-2965.
[12] Rauber S, Luber M, Weber S, et al. Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells [J]. Nat Med, 2017, 23(8): 938-944.
[13] Lobo-Silva D, Carriche GM, Castro AG, et al. Balancing the immune response in the brain: IL-10 and its regulation [J]. J Neuroinflammation, 2016, 13(1): 297.
[14] Soroosh P, Doherty TA, Duan W, et al. Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance [J]. J Exp Med, 2013, 210(4): 775-788.
[15] King A, Balaji S, Le LD, et al. Regenerative wound healing: the role of interleukin-10 [J]. Adv Wound Care, 2013, 3(4): 315-323.
[16] Halim TY, Steer CA, Matha L, et al. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation [J]. Immunity, 2014, 40(3): 425-435.
[17] Liew FY. IL-33: a Janus cytokine [J]. Ann Rheum Dis, 2012, 71 Suppl 2: i101-104. doi: 10.1136/annrheumdis-2011-200589.
[18] Kotsiou OS, Gourgoulianis KI, Zarogiannis SG. IL-33/ST2 axis in organ fibrosis [J]. Front Immunol, 2018, 9:2432. doi: 10.3389/fimmu.2018.02432.
[19] Lunderius-Andersson C, Enoksson M, Nilsson G. Mast cells respond to cell injury through the recognition of IL-33 [J]. Front Immunol, 2012, 3: 82. doi: 10.3389/fimmu.2012.00082.
[20] Yin H, Li X, Hu S, et al. IL-33 accelerates cutaneous wound healing involved in upregulation of alternatively activated macrophages [J]. Mol Immunol, 2013, 56(4): 347-353.
[21] Lopetuso LR, Scaldaferri F, Pizarro TT. Emerging role of the interleukin(IL)-33/ST2 axis in gut mucosal wound healing and fibrosis [J]. Fibrogenesis Tissue Repair, 2012, 5(1): 18.
[22] Sadtler K, Estrellas K, Allen BW, et al. Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells [J]. Science, 2016, 352(6283): 366-370.
[23] Farhadihosseinabadi B, Salimi M, Kazemi B, et al. Inducing type 2 immune response, induction of angiogenesis, and anti-bacterial and anti-inflammatory properties make Lacto-n-Neotetraose(LNnT)a therapeutic choice to accelerate the wound healing process [J]. Med Hypotheses, 2020, 134: 1093890. doi: 10.1016/j.mehy.2019.109389.
[24] Wu J, Hayes BW, Phoenix C, et al. A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections [J]. Nat Immunol, 2020, 21(6): 671-683.
[25] Bal SM, Golebski K, Spits H. Plasticity of innate lymphoid cell subsets [J]. Nat Rev Immunol, 2020, 20(9): 552-565.
[26] Panda SK, Colonna M. Innate lymphoid cells in mucosal immunity [J]. Front Immunol, 2019, 10: 861. doi: 10.3389/fimmu.2019.00861.
[27] Halim TY, Krauss RH, Sun AC, et al. Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation [J]. Immunity, 2012, 36(3): 451-463.
[28] Zhu P, Zhu X, Wu J, et al. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3 [J]. Nat Immunol, 2019, 20(2): 183-194.
[29] Besnard AG, Guabiraba R, Niedbala W, et al. IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells [J]. PLoS Pathog, 2015, 11(2): e1004607. doi:10.1371/journal.ppat.1004607.
[30] Rak GD, Osborne LC, Siracusa MC, et al. IL-33-dependent group 2 innate lymphoid cells promote cutaneous wound healing [J]. J Invest Dermatol, 2016, 136(2): 487-496.
[31] Kumar V. Innate lymphoid cells and adaptive immune cells cross-talk: a secret talk revealed in immune homeostasis and different inflammatory conditions [J]. Int Rev Immunol, 2021, 40(3): 217-251.
[32] Mirchandani AS, Besnard AG, Yip E, et al. Type 2 innate lymphoid cells drive CD4+ Th2 cell responses [J]. J Immunol, 2014, 192(5): 2442-2448.
[33] Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis [J]. Immunity, 2016, 44(3): 450-462.
[34] Godwin JW, Pinto AR, Rosenthal NA. Macrophages are required for adult salamander limb regeneration [J]. Proc Natl Acad Sci U S A, 2013, 110(23): 9415-9420.
[35] Tidball JG, Wehling-Henricks M. Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo [J]. J Physiol, 2007, 578(Pt 1): 327-336.
[36] Kimball AS, Davis FM, Dendekker A, et al. The histone methyltransferase setdb2 modulates macrophage phenotype and uric acid production in diabetic wound repair [J]. Immunity, 2019, 51(2): 258-71 e5. doi: 10.1016/j.immuni.2019.06.015.
[37] Liu Y, Li Y, Li N, et al. TGF-beta1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21 [J]. Sci Rep, 2016, 6: 32231. doi: 10.1038/srep32231.
[38] Iredale JP, Thompson A, Henderson NC. Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation [J]. Biochim Biophys Acta, 2013, 1832(7): 876-883.
[39] Rosenberg HF, Dyer KD, Foster PS. Eosinophils: changing perspectives in health and disease [J]. Nat Rev Immunol, 2013, 13(1): 9-22.
[40] Heredia JE, Mukundan L, Chen FM, et al. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration [J]. Cell, 2013, 153(2): 376-388.
[41] Inclan-Rico JM, Ponessa JJ, Valero-Pacheco N, et al. Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [J]. Nat Immunol, 2020, 21(10): 1181-1193.
[42] Walker JA, Mckenzie ANJ. TH2 cell development and function [J]. Nat Rev Immunol, 2018, 18(2): 121-133.
[43] Kim S, Prout M, Ramshaw H, et al. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3 [J]. J Immunol, 2010, 184(3): 1143-1147.
[44] Lloyd CM, Snelgrove RJ. Type 2 immunity: Expanding our view [J]. Sci Immunol, 2018, 3(25): eaat1604. doi: 10.1126/sciimmunol.aat1604.
[45] Ozpinar EW, Frey AL, Cruse G, et al. Mast cell-biomaterial interactions and tissue repair [J]. Tissue Eng Part B Rev, 2021. doi: 10.1089/ten.TEB.2020.0275.
[46] Zimmermann C, Troeltzsch D, Giménez-Rivera VA, et al. Mast cells are critical for controlling the bacterial burden and the healing of infected wounds [J]. Proc Natl Acad Sci U S A, 2019, 116(41): 20500-20504.
[47] De Souza Junior DA, Borges AC, Santana AC, et al. Mast cell proteases 6 and 7 stimulate angiogenesis by inducing endothelial cells to release angiogenic factors [J]. PLoS One, 2015, 10(12): e0144081. doi: 10.1371/journal.pone.0144081.
[48] Wulff BC, Parent AE, Meleski MA, et al. Mast cells contribute to scar formation during fetal wound healing [J]. J Invest Dermatol, 2012, 132(2): 458-465.
[1] LIU Teng, MA Yingchun. Expression of ECT2 in uterine corpus endometrial carcinoma and its clinical significance based on bioinformatics database [J]. Journal of Shandong University (Health Sciences), 2022, 60(8): 63-71.
[2] ZHANG Weiwei, HUA Fang, LIANG Chaoshuai, CHU Miaomiao, SUN Jiayi, FRANK Zaucke, XIN Wei. Thyroid stimulating hormone promotes chondrocyte differentiation via anti-inflammatory protein CTRP3 [J]. Journal of Shandong University (Health Sciences), 2022, 60(10): 1-8.
[3] ZHANG Zhaoying, MA Chunhong. Immunomodulatory effects of bile acid in hepatointestinal diseases [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 30-36.
[4] QIAO Chong, WANG Tingting. Research progress of maternal-fetal immunomodulatory mechanism [J]. Journal of Shandong University (Health Sciences), 2021, 59(8): 24-31.
[5] LI Xiangqing, YIN Xin, ZHAO Xuelian, ZHAO Peiqing. Expression and clinical significance of circulating CD56bright subset of NK cells in patients with Parkinsons disease [J]. Journal of Shandong University (Health Sciences), 2021, 59(2): 34-40.
[6] WANG Yan, ZHANG Yuhui, HU Naibo, TENG Guangshuai, ZHOU Yuan, BAI Jie. Characteristics of bone marrow immune microenvironment in patients with acute myeloid leukemia based on single-cell RNA sequencing [J]. Journal of Shandong University (Health Sciences), 2021, 59(10): 30-38.
[7] WANG Qingshi, CHEN Yunzhen, LIU Haichun, WU Wenliang, JIAO Guangjun, LI Xiaofeng, XU Daxia. Effects of inflammatory cytokines secreted by nucleus pulposus cells on proliferation and osteogenic ability of posterior longitudinal ligament fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 22-26.
[8] YUAN Bing, LI Ranran, HAN Mingyong. Primary tumor regulates the pulmonary microenvironment in melanoma carcinoma model and facilitates lung metastasis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 13-18.
[9] LI Xiuhua, LI Xiaoli, DUAN Ruisheng, ZHU Meijia, CAO Lili, LI Yanbin, WANG Si, YUE Longtao, MA Qinghai, LIU Fei. Effects of 1,25(OH)2D3 on the induction of immune tolerance in Lewis rats with EAMG [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(8): 5-10.
[10] YANG Yong-rong, LI Jun, LIANG Ye, LI Jin-du, LAN Jia-fu, LI Tian-zi. The study on association of TNF-α-238G/A gene polymorphisms in patients with oral lichen planus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S1): 10-11.
[11] CHEN Guoling, REN Ran, ZHANG Yinghui, SONG Wei, KAO Xin, ZHANG Han. Significance and effect of emodin on activation of nuclear factor-κB in corneas of keratitis rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(9): 44-47.
[12] WU Fengjuan, LI Tao, QI Qian, LI Yu. Effects of azithromycin and dexamethasone on the secretion of ICAM-1 and TNF-α in A549 cells stimulated with Aspergillus fumigatus conidia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(10): 25-28.
[13] LIU Lu1, ZHANG Wen1, CHEN Han-xiang1, ZHENG Lin1, LU Yi2,WANG Hong1， TANG Wei1, ZHAO Wei-ming1. Inflammatory responses of PGRN-deficient peritoneal macrophage to bacterial lipopolysaccharide in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(3): 58-62.
[14] ZHANG You-can1,2, GUO Hui2, REN Xiao-hong2, LIU Guang-guo2, SHAO Luo-lin2, LI Chun-yang1. p38 MAPK mediates production of CCL27 by calcitonin
gene-related peptide-stimulated HaCaT cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(4): 76-.
[15] SUN Lei1，WU Jing-jing2，YI Shou-nan2，CHEN Li1. Isolation and amplification of human CD4+CD25+ regulatory T cells in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(12): 1-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] SUN Wei-peng,ZOU Wei-wei,XI Yan-wei,ZHANG Na. Oral absorption effect of liposomes with different sizes on TFu[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(6): 639 -642 .
[2] XIAO Wei-ling,LIN Ya-jie,MU Dong-zhen,SUN Ping,LIANG Shu-juan. Recombinational expression of classical pathway secreted human IL-1β in hepatoma H7402 cells[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(2): 119 -122 .
[3] YU Qing-mei,WU Yu-ling,SONG Hai-yan,YIN Hua-wei,ZHUANG Yuan. Expression of p38 mitogen-activated protein kinase in early embryos and the peri-implantation endometrium in mice[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(2): 123 -127 .
[4] ZHANG Yong,YE Jing,GUO Xin-xing,XIAO Shui-qing. Immunohistochemical expression of IL-8 in pulpal tissues on orthodontic rapid tooth movement through distraction osteogenesis of the periodontal ligament[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(4): 379 -381 .
[5] GAO Jing,CHEN Wen,ZHANG Tong-xia,WANG Xiao-hua,DAI Ting-jun,YAO Hong,ZHAO Xiu-he,CHI Zhao-fu,SHAN Pei-yan. Changes of expression of mitochondrial cytochrome oxidase subunits Ⅲ and Ⅳ in the rat hippocampus of temporal lobe epilepsy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(8): 817 -820 .
[6] . Expression and significance of stem cell marker LGR5 proteins in the  development  and progression of human colorectal carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(8): 85 -88 .
[7] LIU Yimin, DU Lutao, WANG Lili, JIANG Xiumei, LI Juan, QU Ailin, WANG Haiyan, ZHENG Guixi, ZHANG Xin,YANG Yongmei, WANG Chuanxin. Identification and validation of suitable reference genes for the investigation of serum microRNA in bladder cancer patients[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(5): 86 -91 .
[8] YANG Kui-zhong,SUN Xue-fei,XIANG Ji-shun,DU Qing-cong,HUANG Feng-chang. Inhibitory effect of c-FLIP-ASODN on transplantation tumor of esophagus cancer cell line EC109 in nude mice: an experimental study[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(12): 1234 -1238 .
[9] YU Xin-shuang,HAN Jun-qing,WANG Xing-wen,SHENG Wei,WANG Yu. Relationship between cytoimmunologic status and prognosis of patients with breast cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(9): 934 -937 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(7): 751 -752 .
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd