Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (9): 51-56.doi: 10.6040/j.issn.1671-7554.0.2021.0961

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Role and regulatory mechanism of type 2 immunity in tissue repair

GE Shaohua, DING Tian, LIU Hongrui   

  1. Department of Periodontology, School and hospital of Stomatology, Shandong University, Jinan 250012, Shandong, China
  • Published:2021-10-15

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Abstract: The repair and regeneration of damaged tissue has always been a research hotspot in regenerative medicine. Traditional regenerative medicine relies on stem cell, growth factor, and scaffold to achieve tissue regeneration, but the safety and effectiveness in the clinic still need to be verified. In recent years, growing evidences have shown that the immune system is crucial in tissue repair and regeneration, which provides a new avenue for regenerative medicine. Type 2 immunity, involved in various immune cell subsets, is characterized by the production of interleukin(IL)-4, IL-5, IL-9, IL-10, IL-13, and IL-33. It plays a key role in regulating the immune environment during tissue repair. This paper reviews the role and regulatory mechanism of type 2 cytokines and individual immune cell subsets in tissue repair and regeneration following injury.

Key words: Type 2 immunity, Tissue repair, Immune cell, Cytokines

CLC Number: 

  • R392
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