Journal of Shandong University (Health Sciences) ›› 2017, Vol. 55 ›› Issue (12): 88-94.doi: 10.6040/j.issn.1671-7554.0.2017.870

Previous Articles     Next Articles

Changes in prescriptions for upper respiratory tract infections in Z county of Shandong Province:a panel data analysis of 8 village clinics

YANG Ding1,YANG Peng2, LI Yubo2, SUN Qiang1   

  1. 1. School of Health Care Management, Shandong University;
    Key Laboratory of Health Economics and Policy Research NHFPC(Shandong University), Jinan 250012, Shandong, China;
    2. Zhucheng Center for Disease Control and Prevention, Zhucheng 262200, Shandong, China
  • Online:2017-12-20 Published:2022-09-27

Abstract: Objective To analyze prescription patterns of patients with upper respiratory tract infections(URTIs)at village clinics in Shandong Province and to provide references to promote rational use of drugs in rural areas. Methods Probability-proportional-to-size sampling method was used to select prescriptions with URTIs(n=4 359)from 8 village clinics in Z county in Shandong Province between March 2015 and February 2017. Prescription patterns and trends were analyzed using linear regression model. Results Among the 4 359 prescriptions with URTIs, the proportion of antibiotic prescriptions decreased(β=-0.009, P<0.001). And the rate of third-generation cephalosporins revealed gradual increase(β=0.001, P=0.038). The proportion of Chinese Patent Medicine prescriptions was increased(β=0.003, P=0.028). The proportion of antibiotic prescriptions decreased in four age groups: under 15 years, 16 to 44 years, 45 to 59 years and above 60 years. Meanwhile, the proportion of prescribing non-steroidal anti-inflammatory drugs 山 东 大 学 学 报 (医 学 版)55卷12期 -杨丁,等.基于面板数据的村卫生室上呼吸道感染处方用药变化规律——以山东省Z县8个村卫生室为例 \=-and corticosteroids to patients under 15 years old and above 60 years old decreased. Conclusion Antibiotic prescriptions for URTIs decreased notably, while Chinese Patent Medicine prescriptions increased. However, the rate of antibiotics use was still high, especially of broad spectrum antibiotics.

Key words: Antibiotics, Upper respiratory tract infections, Trend, Shandong Province, Village clinics

CLC Number: 

  • R951
[1] 王文华, 尹爱田, 宋春燕. 山东省农村地区住院常见病可分流病种研究[J]. 中国卫生事业管理, 2011, 28(1): 212-214. WANG Wenhua, YIN Aitian, SONG Chunyan. Studying the rural referral inpatients with common diseases in Shandong Province[J]. The Chinese Health Service Management, 2011, 28(1): 212-214.
[2] 杨晓燕, 王世强, 王雄彪. 急诊感冒患者抗菌药物应用现状[J]. 医药导报, 2017, 36(6): 691-694.
[3] 王轶, 高胜改. 普通感冒治疗中抗菌药物应用情况及原因分析[J]. 河北联合大学学报, 2013, 15(3): 357-358.
[4] Donnelly JP, Baddley JW, Wang HE. Antibiotic utilization for acute respiratory tract infections in U.S. emergency departments[J]. Antimicrob Agents Chemother, 2014, 58(3): 1451-1457.
[5] Tang Y, Liu C, Zhang X. Performance associated effect variations of public reporting in promoting antibiotic prescribing practice: a cluster randomized-controlled trial in primary healthcare settings[J]. Prim Health Care Res Dev, 2017, 18(5): 482-491.
[6] 任晓华, 黄东红, 夏大,等. 益阳市基层医疗机构门诊处方行为的综合评价[J]. 中南大学学报(医学版), 2016,41(2): 182-190. REN Xiaohua, HUANG Donghong, XIA Da, et al. Comprehensive evaluation on the prescription behavior for outpatients in primary health care institutions of Yiyang[J]. J Central South Univ(Med Ed), 2016, 41(2): 182-190.
[7] 丁李路. 农村居民抗生素认知、态度和使用行为研究[D]. 济南: 山东大学, 2016.
[8] World Health Organization. WHO collaborating centre for drug statistics methodology[EB/OL].(2016-12-19)[2017-06-20]. https://www.whocc.no/atc_ddd_index/.
[9] World Health Organization. How to investigate drug use in health facilities: selected drug use indicators[R]. Geneva: WHO, 1993.
[10] Adriaenssens N, Coenen S, Tonkin-Crine S, et al. European Surveillance of Antimicrobial Consumption(ESAC): disease-specific quality indicators for outpatient antibiotic prescribing[J]. BMJ Qual Saf, 2011, 20(9): 764-772.
[11] 龙凤, 张诗琦, 杨波, 等. 普通感冒患者抗生素使用及其影响因素分析——以四川省为例[J]. 教育教学论坛, 2016(40): 66-67.
[12] 刘海燕, 汪俊华, 蒋芝月, 等. 贵州市某区基层医疗卫生机构门诊处方用药情况分析[J]. 贵州医科大学学报(医学版), 2017, 42(8): 893-896. LIU Haiyan, WANG Junhua, JIANG Zhiyue, et al. Analysis on the outpatient prescription in primary medical institutions in Guiyang[J]. Journal of Guizhou Medical University, 2017, 42(8): 893-896.
[13] 李秀霞, 顾文静, 张静芸, 等. 甘肃省农村地区医疗用药合理性分析[J]. 中国公共卫生, 2017, 33(3): 419-421. LI Xiuxia, GU Wenjing, ZHANG Jingyun. Rationality of medicine use in rural areas of Gansu province[J]. Chinese Journal of Public Health, 2017, 33(3): 419-421.
[14] 何瑾, 龙晓东, 普燕芳, 等. 云南省乡村医生抗菌药物、糖皮质激素认知及使用情况的调查分析[J]. 中国药房, 2016, 27(3): 299-302. HE Jin, LONG Xiaodong, PU Yanfang. Investigation and analysis of cognition and application about antibiotics and glucocorticoids among rural doctors in Yunnan Province[J]. China Pharmacy, 2016, 27(3): 299-302.
[15] Kho BP, Ong CM, Tan FT, et al. Antibiotic prescribing for upper respiratory tract infections in sarawak district hospitals[J]. Med J Malaysia, 2013, 68(2): 136-140.
[16] Kotwani A, Holloway K. Trends in antibiotic use among outpatients in New Delhi, India[J]. Bmc Infectious Diseases, 2011, 11(1): 1-9.
[17] Gulliford M, Latinovic R, Charlton J, et al. Selective decrease in consultations and antibiotic prescribing for acute respiratory tract infections in UK primary care up to 2006[J]. J Public Health(Oxf), 2009, 31(4): 512-520.
[18] 阴佳. 山东、宁夏两省农村地区药品使用的评价研究[D]. 济南: 山东大学, 2009.
[19] Sun Q, Dyar OJ, Zhao L, et al. Overuse of antibiotics for the common cold-attitudes and behaviors among doctors in rural areas of Shandong Province, China[J]. BMC Pharmacol Toxicol, 2015, 16(1): 1-6.
[20] 蔡文强, 周子君. 北京市三级综合医院门诊抗生素使用情况分析[J]. 现代预防医学, 2017, 44(5): 954-960. CAI Wenqiang, ZHOU Zijun. Antibiotics use in tertiary general hospital out patient clinic, Beijing[J]. Modern Preventive Medicine, 2017, 44(5): 954-960.
[21] 胡付品, 朱德妹, 汪复, 等. 2014年CHINET中国细菌耐药性监测[J]. 中国感染与化疗杂志, 2015, 15(5): 401-410. HU Fupin, ZHU Demei, WANG Fu, et al. CHINET 2014 surveillance of bacterial resistance in China[J].Chin J Infect Chemother, 2015, 15(5): 401-410.
[22] 王继成. 抗生素滥用的根源、危害及合理使用的策略[J].中国医药指南, 2014, 12(28): 202-203.
[23] 中华人民共和国国务院. 2009年中共中央国务院关于深化医药卫生体制改革的意见[EB/OL].(2009-03-17)[2017-06-15]. http://www.gov.cn/jrzg/2009-04/06/content_1278721.htm.
[24] 中华人民共和国卫生和计划生育委员会. 卫生部卫生厅. 2011年全国抗菌药物临床应用专项整治活动方案[EB/OL].(2011-04-18)[2017-06-15]. http://www.nhfpc.gov.cn/zwgkzt/wsbysj/201104/51376.shtml.
[25] 中华人民共和国卫生和计划生育委员会. 2012年全国抗菌药物临床应用专项整治活动方案[EB/OL].(2012-03-05)[2017-6-15]. http://www.nhfpc.gov.cn/zwgkzt/wsbysj/201203/54251.shtml.
[26] 中华人民共和国卫生和计划生育委员会. 2013年全国抗菌药物临床应用专项整治活动方案[EB/OL].(2013-05-06)[2017-06-15]. http://www.nhfpc.gov.cn/zwgk/wtwj/201305/823b9d131ff4416ab7b41b2c4e1f0e83.shtml.
[27] 中华人民共和国国家卫生和计划生育委员会. 国家卫生计生委办公厅关于做好2014年抗菌药物临床应用管理工作的通知[EB/OL].(2014-04-14)[2017-06-15]. http://www.nhfpc.gov.cn/yzygj/s3593/201404/49973560ddde4293a489b158081d777c.shtml.
[28] 中华人民共和国国家卫生和计划生育委员会办公厅. 抗菌药物临床应用指导原则(2015年版)[EB/OL].(2015-07-24)[2017-06-15]. http://www.nhfpc.gov.cn/yzygj/s3593/201508/c18e1014de6c45ed9f6f9d592b43db42.shtml.
[29] Li J, Song X, Yang T, et al. A systematic review of antibiotic prescription associated with upper respiratory tract infections in China[J]. Medicine, 2016, 95(19): e3587. doi: 10.1097/MD.0000000000003587.
[30] 中国医师协会呼吸医师分会, 中国医师协会急诊医师分会, 林江涛. 普通感冒规范诊治的专家共识[J]. 中国急救医学, 2012, 32(11): 961-965.
[31] 陆权, 安淑华, 艾涛, 等. 中国儿童普通感冒规范诊治专家共识(2013年)[J]. 中国实用儿科杂志, 2013, 28(9): 680-686.
[32] Sun J, Shen X, Li M, et al. Changes in patterns of antibiotic use in Chinese public hospitals(2005-2012)and a benchmark comparison with Sweden in 2012[J]. J Glob Antimicrob Resist, 2015, 3(2): 95-102.
[1] AN Yuanxiaoxue, DU Yiming, TIAN Tian, ZHANG Yi, XUE Yuwen. Pulmonary infection caused by Nocardia pneumoniae and Nocardia amamiensis: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2022, 60(3): 59-63.
[2] WANG Zhouyang, JIANG Bei, LI Xianhua, ZHEN Junhui, YANG Xiangdong, HU Zhao, LIU Guangyi, PEI Fei. A case of infective endocarditis and acute kidney injury with positive PR3-ANCA [J]. Journal of Shandong University (Health Sciences), 2022, 60(2): 60-64.
[3] Jianhua JU,Zhenye YANG,Qinglian LI,Ya'nan HAN,Yanqing LI,Yijun QIAO,Hu YANG,Huaran ZHANG. Advances on drugs derived from microbial sources and future perspectives [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 43-50,63.
[4] PENG Xiumiao, WANG Xuefeng, GONG Weimei, ZHANG Yang, ZHOU Jingwen, CUI Liangliang. Concentration changes and health risk of 8 heavy metals in drinking water in Jinan from 2016 to 2020 [J]. Journal of Shandong University (Health Sciences), 2021, 59(12): 24-32.
[5] SUN Chengyao, TANG Dajing, CHEN Fengge, ZHAO Chuan, GUAN Mingyang. Trend and health risk assessment of chemical components in atmospheric PM2.5 in Shijiazhuang City from 2016 to 2020 [J]. Journal of Shandong University (Health Sciences), 2021, 59(12): 78-86.
[6] LU Kailai, BAN Jie, FEI Xianyun, ZHOU Zhen, LI Tiantian. Trend of heatwave events and population exposure levels in China from 2005 to 2017 [J]. Journal of Shandong University (Health Sciences), 2021, 59(12): 158-164.
[7] CAO Aihua, DUAN Chunhong, QIU Bingping, LU Ling, LI Keliang, LIU Xuegong, ZHOU Zhiyuan, SUN Jianhua, JU Xiuli. Epidemiological and clinical characteristics of children infected with SARS-CoV-2 in Shandong Province [J]. Journal of Shandong University (Health Sciences), 2020, 58(6): 34-40.
[8] ZHOU Shengyu, WANG Chunting, ZHANG Wei, WANG Ximing, DONG Liang. Clinical characteristics and treatment effect of 537 cases of novel coronavirus pneumonia in Shandong Province [J]. Journal of Shandong University (Health Sciences), 2020, 58(3): 44-51.
[9] LIN Mengmeng, LIU Yang, GAO Rong, YU Zhixia, GAO Lijie, WANG Zhiping. Relevant research on macrosomia from 1999 to 2018 [J]. Journal of Shandong University (Health Sciences), 2020, 58(2): 109-117.
[10] LIU Guanyi, YANG Liyuan, FU Zhentao, XU Aiqiang, GUO Xiaolei. Incidence and mortality of oral cancer in Shandong Province in 2014 [J]. Journal of Shandong University (Health Sciences), 2019, 57(7): 102-107.
[11] HE Dongyang, SUN Jiyao, WANG Meng, WANG Jian, HUANG Guo. Comparison of the characteristics of inpatients’ disease distribution in a tertiary hospital in Shandong Province in 2006 and 2016 [J]. Journal of Shandong University (Health Sciences), 2018, 56(4): 81-86.
[12] ZHAO Qingqing, YIN Geping. Association between genetic polymorphisms of 5 genetic loci of TNF-α promoter and genetic susceptibility to cervical cancer [J]. Journal of Shandong University (Health Sciences), 2018, 56(2): 28-33.
[13] CUI Yi, YIN Mei, LI Wei, LI Yuan, HAN Hui, SHAN Tichao, YUE Jinfeng, DING Shifang, LI Chen, CHEN Xiaomei, WU Dawei, WANG Hao. Changes of the incidence, antibiotic resistance, antibiotic therapy and prognosis in patients with Staphylococcus aureus bloodstream infection in Qilu Hospital of Shandong University [J]. Journal of Shandong University (Health Sciences), 2018, 56(12): 33-38.
[14] WANG Meijian, HOU Xinguo, LIANG Kai, CHEN Li. Serum lipids and lipoproteins in middle-aged and elderly Chinese in Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 70-75.
[15] LI Yan, LIU Kun, SUN Xiaojie. Health inequality related to income and influencing factors of the rural elderly in three counties of Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 91-96.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] SHAO Haigang, WANG Xuan, WANG Qing. Anatomy of the root canal system of mandibular first premolar in population of Shandong Province[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(9): 85 -89 .
[2] XU Jie,TIAN Hui,LIU Xian-xi,ZHANG Bing,LI Wen-jun,SONG Xu. Apoptotic effects of ODC and AdoMetDC bi-antisense virus on esophageal cancer cell Eca109[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(10): 936 -940 .
[3] . Valuation of theoretical immune response status of HBV multiepitope 
vaccines in existence in the population of China
[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(10): 114 -117 .
[4] . Apoptosis of corneal epithelium in ReisBücklers corneal dystrophies[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(10): 130 -133 .
[5] LIU Yanxia1,2, ZHANG Feng2, WANG Xin1. Expression of differential genes in placental vascular disease  and normal placenta through gene arrays[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(1): 131 -134 .
[6] ZHANG Yi-ming,ZHANG Xiang-ning. Expression of XIAP, Survivin, LPA and CA125 in human epithelial ovarian carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(3): 317 -321 .
[7] . Improvement and application of comparative genomic hybridization in prenatal diagnosis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(7): 89 -92 .
[8] ZHANG Min1, GENG Hou-fa2, SUN Lin2. Quantitative evaluation of brain metabolic changes in patients with acute cerebral infarction and type 2 diabetes mellitus using proton magnetic resonance spectroscopy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(11): 74 -77 .
[9] WANG Tong, LIU Yu-guang, ZHANG Liang-wen, WANG Hong-wei, LI Lian-ling, LIU Zhi-guo. Effect of inhibiting EGFR and mTOR signaling pathway on C6 glioma and its stem cells[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(5): 37 -43 .
[10] ZHANG Jijuan, YU Hancheng, WANG Lan, CHEN Nuo, CUI Shumeng, Gao Xibao. Effects of high-fat diet and selenium concentration on antioxidant function in rats[J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 95 -101 .