Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (12): 33-38.doi: 10.6040/j.issn.1671-7554.0.2018.466

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Changes of the incidence, antibiotic resistance, antibiotic therapy and prognosis in patients with Staphylococcus aureus bloodstream infection in Qilu Hospital of Shandong University

CUI Yi1, YIN Mei2, LI Wei3, LI Yuan1, HAN Hui1, SHAN Tichao1, YUE Jinfeng1, DING Shifang1, LI Chen1, CHEN Xiaomei1, WU Dawei1, WANG Hao1   

  1. 1. Intensive Care Unit;
    2. Department of Geriatrics;
    3. Department of Laboratory, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To investigate the changes of the incidence, antibiotic resistance, antibiotic therapy and prognosis in patients with Staphylococcus aureus bloodstream infection(SABI)in Qilu Hospital of Shandong University in recent 山 东 大 学 学 报 (医 学 版)56卷12期 -崔毅,等. 山东大学齐鲁医院金黄色葡萄球菌血流感染发生率、菌株耐药性、抗菌药物使用及预后变化 \=-years. Methods The basic information of patients with SABI were retrospectively collected from January 2009 to December 2010(17 cases, A group)and from January 2015 to December 2016(32 cases, B group). The pathogen, laboratory and clinical data were also collected. Acute Physiology and Chronic Health Evaluation II(APACHEⅡ)score and Sequential Organ Failure Assessment(SOFA)score were then calculated. The incidence of SABI, the incidence of antibiotic resistance, antibiotic treatment, patient outcome and 28-day mortality were compared between these two groups. Results Compared with A group, the incidence and 28-day mortality of SABI in B group decreased(1.5 vs 1.1; 29.1% vs 18.8%)with no statistical difference(both P>0.05)in our hospital. The difference between the two groups in the basic information of SABI patients(including sex, age, length of stay, distribution of departments and primary diseases), hospitalization cost, primary source of bloodstream, and the severity of illness(including the rate of mechanical ventilation and renal replacement therapy, the incidence of septic shock, APACHE II score and SOFA score)were not statistically significant(all P>0.05). The proportion of methicillin-resistant Staphylococcus aureus(MRSA)in isolates increased with no statistical difference(P>0.05). The resistance rates of the isolates to penicillin, ciprofloxacin, vancomycin and linazolamide did not differ significantly(all P>0.05). No vancomycin or linezolid resistant strains were found in the both groups. The patients in A group received significantly more antibiotic therapy of glycopeptide antibiotics and less antibiotic therapy of β-lactamase antibiotics for targeted antimicrobial therapy compared with B group(χ2=5.244,P=0.022; χ2=4.895,P=0.027). Conclusion In the recent 8 years, the incidence and 28-day mortality of SABI decreased, while the isolation proportion of MRSA increased in Qilu Hospital of Shandong University. The usage of glycopeptide antibiotics was more and more common.

Key words: Staphylococcus aureus, Bloodstream infection, Antibiotics, Bacterial resistance, Prognosis

CLC Number: 

  • R515
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