JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (11): 33-37.doi: 10.6040/j.issn.1671-7554.0.2014.194

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Dynamics of fasting glucagon and fasting glucagon /insulin ratio with diabetes duration in patients with type 2 diabetes

TIAN Meng, WU Chuanlong, QI Lin, LIU Yan, WANG Chuan, ZHAO Ruxing, LIANG Kai, SONG Jun, HOU Xinguo, CHEN Li   

  1. Department of Endocrinology, Qilu Hospital of Shangdong University, Jinan 250012, Shandong, China
  • Received:2014-04-08 Published:2014-11-10

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Abstract: Objective To analyze the dynamics of fasting glucagon (FGLC) and glucagon /insulin (FGLC/FINS) ratio with diabetes durations and their correlations with glycemic control in patients with type 2 diabetes. Methods Two hundred and sixty-two patients with type 2 diabetes were enrolled and divided into five groups according to diabetes duration: <5 years (group A, n=65); ≥ 5 years and <10 years (group B, n=62); ≥10 years and <15 years (group C, n=46); ≥15 years and <20 years (group D, n=45);≥20 years (group E, n=44). FGLC, fasting insulin (FINS), FGLC/FINS ratio, C peptide, HOMA-IR, HOMA-β and other metabolic indicators were measured to explore their correlations with diabetes duration, fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c). Results FGLC levels of groups A, B and C increased progressively with diabetes duration(r=0.243, P<0.05). Oppositely, FGLC levels of groups D and E were lower than that of group C (P<0.05) and were not correlated with diabetes duration. FGLC/FINS ratio was positively correlated with diabetes duration (r=0.243, P<0.05). Multiple stepwise regression analysis showed that the FGLC/FINS ratio was positively correlated with FBG and HbA1c (t=4.474 or 2.212, P<0.05). Conclusion FGLC of patients with type 2 diabetes increased with diabetes duration forthe first 15 years since being diagnosed, then slightly decreased, whereas the FGLC/FINS ratio consistently increased with diabetes duration. The FGLC/FINS ratio might significantly affect the glycemic control in patients with type 2 diabetes.

Key words: Type 2 diabetes, Glucagon, Glucagon/insulin ratio, Duration

CLC Number: 

  • R587.1
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