JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (2): 82-85.doi: 10.6040/j.issn.1671-7554.0.2013.566

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Expression and clinical significance of protein tyrosine phosphatase SHP-2 in oral squamous cell carcinoma

WANG Hua-chun1, HUANG Sheng-yun2, XIE Hong-jun1, LIU Wen-lei1, ZHANG Jie3, ZHANG Dong-sheng1,2   

  1. 1. School of Stomatology of Shandong University, Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012， China;
     2. Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021， China;
    3. Medical Research Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2013-10-25 Online:2014-02-10 Published:2014-02-10

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Abstract:

Objective   To explore the expression of tyrosine phosphatase 2 (SHP-2) in oral squamous cell carcinoma and its association with clinical pathological parameters. Methods  A total of 45 specimens of oral squamous cell carcinoma and 8 paracancerous tissues were collected. The SHP-2 expression was detected with immunohistochemistry SP method. The association between SHP-2 expression and the prognostic factors was analyzed. Results  The positive rate of SHP-2 in oral squamous cell carcinoma was 68.9%, which was significantly higher than that in paracancerous tissues (P＜0.05). The SHP-2 expression was significantly correlated with clinical stage, lymph nodes metastasis and histologic grade (P＜0.05). Univariate survival analysis indicated that patients with negative SHP-2 expression had a significantly longer overall survival time compared with patients with positive expression (P＜0.05). Multivariate analysis showed that SHP-2 was not an independent prognostic factor for overall survival. Conclusion  SHP-2 is involved in the carcinogenesis and metastasis of oral squamous cell carcinoma, whose expression may serve as a future marker for the prognosis of this carcinoma.

Key words: Immunohistochemistry, Oral squamous cell carcinoma, Protein tyrosine phosphatases 2

CLC Number: 

  • R739.8
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