JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression of villin in precancerous lesions and gastric
carcinoma and its clinical significance

ZHAO Chengbo1, ZHOU Chengjun2, GUO Jianqiang2
   

  1. (1. Shandong University School of Medicine, Jinan 250100, China;
    2. Department of Digestive Disease, Second Hospital of Shandong University, Jinan 250033, China；
    3. Second Department of Medicine, Jiyang County People′s Hospital, Jinan 251400, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-02-16 Published:2009-02-16
  • Contact: GUO Jianqiang

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Abstract: To explore expression of villin in normal gastric mucosa tissues, intestinal metaplasia(IM), dysplasia, and gastric carcinoma and its clinical significance. MethodsAn immunohistochemical method was used to determine villin expression. ResultsVillin was expressed in dysplasia cells but not in gastric mucosa. The positive rates of its expression in intestinal metaplasia, dysplasia, and gastric carcinoma were 85.0%(17/20), 66.7% (20/30), and 48.3%(29/60), respectively. It was also found that expression of villin had no relationship to tumor size, invasiveness, and clinical stage and metastasis to lymphnodes(P>0.05), however, expression of villin was significantly higher in well moderately differentiated cancers than in poorly differentiated ones (P<0.05). ConclusionExpression of villin in precancerous lesions and gastric carcinoma is downregulated and is closely related to tumor differentiation degrees. Villin is a good marker for screening different types of gastric carcinoma and has a certain guiding sense to early diagnosis and clinical treatment.

Key words: Villin, Precancerous conelitions, Gastric carcinoma, Immunohistochemistry

CLC Number: 

  • R730.45
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