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CK5/6 expression in human breast cancer with tissue micro-array and its clinical significance

BI Xiao-feng, GAO Ji-dong, XUAN Li-xue, ZHANG Bao-ning   

  1. Department of Surgical Oncology, Cancer Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100021, China
  • Received:2008-03-12 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: ZHANG Bao-ning

Abstract: To explore the expression of CK5/6 in breast cancer. MethodsThe expression of CK5/6 in 240 breast carcinomas samples was determined by immunohistochemistry with tissue microarray (TMA). ResultsPositive expression ratio of CK5/6 in breast cancer was 14.72%(29/197). CK5/6 expression was not correlated with age, menses, size of tumor, clinical TNM stage, auxiliary lymph nodes metastasis, or pathologic type(P>005)but was correlated with negative expression of ER; Patients with negative CK5/6 expression survived longer than those with positive expression(P<001). Conclusions Positive expression of CK5/6 can result in poor prognosis and it may be one of markers to evaluate the prognosis of breast cancer.

Key words: Breast carcinoma, Tissue microarray, Immunohistochemistry, CK5/6

CLC Number: 

  • R735.8
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