JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect and mechanism of Quduyangxinchongji on viral myocarditis

WANG Feng 1，2,　ZHONG Li-hong3, ZHOU Ya-bin2, YU Qing-tao1, TANG Wei2,
LEI Xue-ming2, PENG Ying2,　YU Han2,　DONG Bo 1，2   

  1. 1. Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China；2. Key Laboratory of Experimental Teratology， Ministry of Education, China； Department of
    Microbiology, School of Medicine, Shandong University, Jinan 250012, China； 3. Department of Pharmaceutics, Qilu Hospital of Shandong University， Jinan 250012， China
  • Received:2007-09-04 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: WANG Feng

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Abstract: To investigate the effect and mechanism of Quduyangxinchongji on viral myocarditis. MethodsSixty male BABL/C mice were randomly divided into the control group, the virus group and the drug group, with 20 mice in each group. Mice in the second and third groups were intraperitoneally inoculated with coxsackievirus B3, while those in the control group were administrated with Eagle′s without coxsackievirus B3. Also the drug group was subjected to Quduyangxinchongji in the stomach after coxsackievirus B3 infection. All mice were killed 21 days later and their hearts were removed for analysis. The levels of IL-6 mRNA expression and protein in the myocardium were respectively determined by real-time PCR and immunohistochchemistry technique. ResultsAs compared with the virus group, the myocardial histopathological scores and mRNA and protein expressions of IL-6 were significantly decreased in the drug group (P＜0.05). ConclusionQuduyangxinchongji might play a pivotal role in viral myocarditis by inhibiting the IL-6 expression in heart tissues.

Key words: Coxsackievirus, Viral myocarditis, Interleukin-6, Mice, BALB C, Quduyangxinchongji

CLC Number: 

  • R542
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