JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of the CD4+ T lymphocyte in the development of viral myocarditis in mice

LIU Zhen-hu, HAN Bo, GUO Chun-yan, CHANG Hong, ZHANG Jie, HAN Xiu-zhen   

  1. Department of Pediatrics, Provincial Hosiptal Affiliated to Shandong University, Jinan 250021, China
  • Received:2007-11-08 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
  • Contact: HAN Bo

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Abstract: ObjectiveTo investigate the effect of the CD4+ T lymphocyte in the development of experimental coxsackievirus B3(CVB3) myocarditis in mice. MethodsA total of 70 BALB/c mice used in the experiments, were randomly divided into the control group and the CVB3 infection group. The mice in the CVB3 infection group were intraperitoneally inoculated with 0.15ml TCID50 109/ml CVB3 and the mice in the control group with 0.15ml eagle reagent. The mice were sacrificed on 7, 10, 14, 21 and 28 days post-inoculation and then the hearts were aseptically removed. Pathological changes in the myocardium were observed by light microscopy and the expression of the CD4+ T lymphocyte in the myocardium was determined by immunohistochemistry. ResultsThe CD4+ T lymphocyte was found in the myocardium in the CVB3 infection group. There was a significantly positive correlation between the expression of the CD4+ T lymphocyte and changes of myocardial histopathological scores（r=0.98, P＜0.01). The expression of the CD4+ T lymphocyte reached a peak during 10 to 14 days（P＜0.01). ConclusionThe CD4+ T lymphocyte leads to myocardial damage while cleaning the virus in experimental CVB3 myocarditis.

Key words: Mice, Myocarditis, Viral diseases, CD4+ T lymphocyte

CLC Number: 

  • R725.4
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