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Relationship between the HPA-2 and Kozak sequence polymorphism of platelet membrane glycoprotein and cerebral infarction

ZHENG Min, HAO Yue-wei, LIU Xue-ping, ZHAO Ting-ting   

  1. Department of Senile Neurology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2007-12-20 Revised:1900-01-01 Online:2008-03-16 Published:2008-03-16
  • Contact: LIU Xue-ping

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Abstract: To explore the relationship between polymorphism of platelet membrane glycoprotein I bα HPA-2 and Kozak sequence and cerebral infarction in the Chinese. MethodsThree hundred and sixteen patients with cerebral infarction confirmed by CT/MRI and two hundred and nine controls were genotyped for the HPA-2 and Kozak polymorphism by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) analysis. ResultsThere were no-significant differences in the HPA-2 genotype frequencies and allele frequencies between cerebra vascular thrombosis patients and controls． The Kozak genotypes with the C allele were 25.95% in the cerebral infarction group compared with those of the control group（18.18%）. Statistical signs showed significant differences (χ2=8.6090, P＜0.01). ConclusionsPlatelet glycoprotein I bα polymorphisms are not associated with cerebral vascular thrombosis in our cohort. The Kozak genotype may be the genetic susceptibility of cerebral vascular thrombosis.

Key words: Glycoprotein, Polymorphism, Cerebral infarction

CLC Number: 

  • R743
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