JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (2): 61-64.doi: 10.6040/j.issn.1671-7554.0.2014.501

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Levels of peripheral blood TNF-α, sTREM-1 and α1-APG in community acquired pneumonia patients

LIN Chen, GUO Fang, JI Weina, YU Wencheng   

  1. Department of Respiratory Medicine, the Affiliated Hospital of Qingdao University, Jinan 266021, Shandong, China
  • Received:2014-07-30 Published:2015-02-10

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Abstract: Objective To observe the changes of tumor necrosis factor-α (TNF-α), soluble triggering receptor-1 expressed on myeloid cells (sTREM-1), and α1-acid glycoprotein (α1-APG) levels in the peripheral blood of patients with community acquired pneumonia (CAP), and to understand their clinical significance in CAP patients. Methods Peripheral blood TNF-α and sTREM-1 levels of 110 CAP patients (CAP group) and 52 normal controls (control group) were detected by ELISA double antibody sandwich method, and peripheral blood α1-APG level was detected by immune turbidity method. The changing trends of TNF-α, sTREM-1 and α1-APG in CAP patients with different states of illness were observed on the 1st, 4th, and 7th days. Results TNF-α, sTREM-1 and α1-APG levels in CAP group on the 1st, 4th and 7th days were significantly higher than those in the control group (P<0.001). After the treatment, the TNF-α, sTREM-1 and α1-APG levels of CAP patients reduced significantly on the 4th day than the 1st day (P<0.001), the TNF-α and sTREM-1 levels on the 7th day reduced significantly than the 4th day (P<0.001), while the α1-APG level on the 7th day rosed than the 4th day (P<0.05). The TNF-α, sTREM-1 and α1-APG levels in PSI high-risk patients were significantly higher than those in middle-risk patients and low-risk patients on the 1st day (P<0.001). The TNF-α, sTREM-1 and α1-APG levels on the 1st day between respiratory failure patients and non-respiratory failure patients had statistical differences (P<0.001). On the 7th day after admission of CAP group, the sTREM-1 and α1-APG levels decreased significantly in glucocorticoid treatment patients than those in non-glucocorticoid treatment patients (P<0.01), but the TNF-α levels in these two groups showed no statistical difference (P>0.05). Conclusion There are excessive releases of inflammatory cytokines, including TNF-α, sTREM-1 and α1-APG, in CAP patients. Application of glucocorticoid can reduce the levels of sTREM-1 and α1-APG. The TNF-α, sTREM-1 and α1-APG levels can reflect the severity of illness and treatment effects of CAP patients, thus can be used as guide indicators for diagnosis, treatment and prognosis of CAP patients.

Key words: α1-acid glycoprotein, Soluble triggering receptor-1 expressed on myeloid cells, Tumor necrosis factor-α, Community acquired pneumonia

CLC Number: 

  • R563
[1] 中国医院协会.单病种质量管理手册[M].北京:科学技术文献出版社, 2011: 93-133.
[2] 中华医学会呼吸病学分会.社区获得性肺炎诊断和治疗指南[J].中华结核和呼吸杂志, 2006, 29(10): 651-655.
[3] Snijders D, van der Eerden M, de Graaff C, et al. The influence of COPD on mortality and severity scoring in community-acquired pneumonia[J]. Respiration, 2010, 79(1): 469-531.
[4] 陈红,刘庆华,郭海生,等.IL-6和sE-选择素与肺炎病情及预后的相关性分析[J].山东大学学报:医学版, 2012, 50(2): 82-86. CHEN Hong, LIU Qinghua, GUO Haisheng, et al.Associations of interleukin-6 and soluble E-selectin with severity and outcome of pneumonia[J]. Journal of Shandong University: Health Sciences, 2012, 50(2): 82-86.
[5] Fermandez-serrano S, Dorca J, Coromines M, et al. Molecular inflammatory responses measured in blood of patients with severe community-acquired pneumonia[J]. Clin Diagn Lab Immunol, 2003, 10(5): 813-820.
[6] Kellum JA, Kong L, Fink MP. Understanding the inflammatory cytokine response in pneumonia and sepsis : results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study[J]. Arch Intern Med, 2007, 167(15): 1655-1663.
[7] Mahdy AM, Lowes DA, Galley HF, et al. Production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involve de novo protein synthesis[J]. Clin Vaccine Immunol, 2006, 13(4): 492-495.
[8] Huh JW, Lim CM, Koh Y, et al. Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates[J]. Crit Care, 2008, 12(1): R6.
[9] 唐朝霞,曾勉,卢桂芳.重症肺炎患者血浆可溶性髓系细胞触发受体1、肿瘤坏死因子α和白细胞介素10水平变化的研究[J].中国呼吸与危重监护杂志, 2011, 10(5): 424-428. TANG Zhaoxia, ZENG Mian, LU Guifang. Changes of plasma levels of soluble triggering receptor expressed on myeloid cell-1, tumor necrosis factor-α and interleukin-10 in severe pneumonia[J]. Chinese Journal of Respiratory and Critical Care Medicine, 2011, 10(5): 424-428.
[10] Kishino S, Nomura A, Zhai SD, et al. Alpha-1-acid glycoprotein concentration and the protein binding of disopyramide in health subjects[J]. J Clin Pharmacol, 1995, 35(5): 510-514.
[11] 李金恒,李勇,宫剑滨,等. 213例健康人血清α1-酸性糖蛋白浓度及其与年龄的相关关系分析[J].南京医科大学学报, 2000, 20(5): 336-338. LI Jinheng, LI Yong, GONG Jianbin, et al. Serum α1-acid glycoprotein concentrations in 213 healthy male subjects and relative analysis with age[J]. Acta Academiae Medicinae Nanjing, 2000, 20(5): 336-338.
[12] 华山,吴成,李林,等.小儿急性肺炎时血清α1-酸性糖蛋白水平及其临床意义[J].安徽医科大学学报, 1996, 31(6): 573-574.
[13] 宋海澄,宋丁,于萍,等.强直性脊柱炎中血清高迁移率族蛋白B1和肿瘤坏死因子-α的表达与疾病相关性的研究[J].中国实验诊断学杂志, 2014, 18(4): 595-598. SONG Haicheng, SONG Ding, YU Ping, et al. Elevated serum level of HMGB1 is associated with disease activity and combined alterations with TNF-alpha in ankylosing spondylitis[J]. Chinese Journal of Laboratory Diagnosis, 2014, 18(4): 595-598.
[14] 韩潞,江勇,韩东兴. α1-酸性糖蛋白在直肠癌组织中的诊断和预后意义[J].中国癌症杂志, 2014, 24(1): 69-72.
[15] Wang HX, Chen B. Diagnostic role of soluble triggering receptor expressed on myeloid cell-l in patients with sepsis[J]. World J Emerg Med, 2010, 1(2): 144-148.
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