JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (2): 12-18.doi: 10.6040/j.issn.1671-7554.0.2014.614

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Effects of statins on patients with chronic obstructive pulmonary disease: a Meta analysis

WU Zhen1, SONG Guodong2, WANG Wei1   

  1. 1. Department of Respiratory, the Second Hospital of Shandong University, Jinan 250033, Shandong, China;
    2. Peking Union Medical College, Beijing 100730, China
  • Received:2014-09-17 Online:2015-02-10 Published:2015-02-10

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Abstract: Objective To evaluate the effects of statins treatment on pulmonary function, exacerbation, inflammatory factors, and health conditions in stable patients with chronic obstructive pulmonary disease (COPD). Methods Databases of PubMed, Cochrane Library, CNKI, Wanfang and VIP were searched up from the day of database construction to November, 2014. Randomized controlled trials (RCTs) which investigated the effects of statins treatment on stable COPD patients were identified. Two independent reviewers screened the retrieved literatures, measured the quality, extracted the data and cross-checked them. RevMan 5.2 statistical software was used to analysis the data. Results Twelve RCTs, including 1 589 patients, were included. Statins treatment reduced the levels of blood inflammatory factors, including serum CRP (WMD:-1.62; 95%CI:-1.90 to -1.34), plasma TNF-α(WMD: -5.31; 95%CI:-9.45 to -1.17) and serum IL-6 (WMD:-0.46; 95%CI:-0.89 to -0.03), alleviated the clinical symptoms, reduced the degree of dyspnea, and improved the life quality. Statins treatment could not improve the forced expiratory volume in 1 second (FEV1), FEV1% predicted (FEV1%pred) and exacerbation. Conclusion Statins treatment has anti-inflammatory effects and can alleviate clinical symptoms, but has no significant effects on reversing the decline of pulmonary function and preventing exacerbation in stable COPD patients.

Key words: Pulmonary disease, chronic obstructive, Statin, Meta analysis, Stable

CLC Number: 

  • R563
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