山东省儿童百日咳感染与哮喘的相关性

doi:10.6040/j.issn.1671-7554.0.2024.0435

山东大学学报 (医学版) ›› 2024, Vol. 62 ›› Issue (7): 33-41.doi: 10.6040/j.issn.1671-7554.0.2024.0435

• 呼吸系统疾病精准诊疗专题 • 上一篇下一篇

山东省儿童百日咳感染与哮喘的相关性

闫金燕^1,2*,杨春^2*,李雷³,吴福玲⁴,焦永莉⁵,张晓蔚⁶,李晶⁷,张瑞珍⁸,王磊⁹,马香^2,10

1.山东大学附属儿童医院感染性疾病科, 山东济南 250022;2.济南市儿童呼吸病重点实验室, 山东大学附属儿童医院, 山东济南 250022;3.山东第一医科大学附属济南妇幼保健院儿科, 山东济南 250001;4.滨州医学院附属医院儿科, 山东滨州 256600;5.枣庄市市中区妇幼保健院儿科, 山东枣庄 277100;6.济南市章丘区人民医院儿科, 山东济南 250200;7.济宁市任城区妇幼保健院儿科, 山东济宁 272005;8.德州市齐河县妇幼保健院儿科, 山东德州 251100;9.泰安市妇幼保健院儿科, 山东泰安 271000;10.山东省儿童疾病及健康研究中心, 济南市儿童医院, 山东济南 250022

发布日期:2024-09-20
通讯作者: 马香. E-mail:maxiang0176@163.com*共同第一作者.
基金资助:
济南市卫生健康委科技计划项目(2022-2-163);山东省医药卫生科技项目(202306011027);山东省儿童健康与疾病临床医学研究中心立项项目(SDPRC009);济南市卫生健康委大数据科技计划项目(2022-YBD-1-06,2022-BD-13);济南市临床科技创新项目(202225022)

Correlation between asthma and pertussis infection in children of Shandong Province, China

YAN Jinyan^1,2*, YANG Chun^2*, LI Lei³, WU Fuling⁴, JIAO Yongli⁵, ZHANG Xiaowei⁶, LI Jing⁷, ZHANG Ruizhen⁸, WANG Lei⁹, MA Xiang^2,10

1. Department of Infectious Diseases, Childrens Hospital Affiliated to Shandong University, Jinan 250022, Shandong, China;
2. Jinan Key Laboratory of Pediatric Respiratory Diseases, Childrens Hospital Affiliated to Shandong University, Jinan 250022, Shandong, China;
3. Department of Pediatrics, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan 250001, Shandong, China;
4. Department of Pediatrics, Binzhou Medical University Hospital, Binzhou 256600, Shandong, China;
5. Department of Pediatric, Shizhong District Maternal and Child Health Care Hospital, Zaozhuang 277100, Shandong, China;
6. Department of Pediatrics, Peoples Hospital of Zhangqiu District, Jinan 250200, Shandong, China;
7. Department of Pediatric, Jining Rencheng District Maternal and Child Care Hospital, Jining 272005, Shandong, China;
8. Department of Pediatric, Qihe Maternity and Childrens Health Care Hospital, Dezhou 251100, Shandong, China;
9. Department of Pediatrics, Taian Maternity and Child Health Care Hospital, Taian 271000, Shandong, China;
10. Shandong Provincial Clinical Research Center for Childrens Health and Disease, Jinan Childrens Hospital, Jinan 250022, Shandong, China

Published:2024-09-20

摘要/Abstract

摘要： 目的通过多中心、前瞻性调查,评估不同分期、不同类型哮喘儿童百日咳的感染情况,并分析哮喘与百日咳的相关性。方法通过调查问卷收集因咳嗽持续时间≥1周而就诊的哮喘儿童相关信息,并进行百日咳毒素(pertussis toxin, PT)IgG抗体浓度和/或百日咳核酸检测,对结果进行判读。根据年龄、哮喘分期、是否合并百日咳感染等进行分组,分析不同分组间百日咳抗体分布、感染情况及临床特点等。结果 1 049例哮喘患儿中,PT-IgG总阳性率为26.22%,其中≥6岁组显著高于3个月~<3岁组和3岁~<6岁组(P均<0.001);百日咳感染率为25.17%,其感染率随年龄段增长而升高(P均<0.001)。咳嗽变异性哮喘合并百日咳感染者显著高于经典哮喘(28.00% vs. 22.59%, P=0.040)。对656例患儿临床特点进行分析发现,哮喘急性发作期患儿合并百日咳感染率高于慢性持续期及临床缓解期(26.15% vs. 10.46%, P<0.001; 26.15% vs. 8.00%, P=0.042);是否合并百日咳在哮喘初诊与复诊患儿之间差异无统计学意义(P=0.189)。哮喘合并百日咳者更易出现痉挛性咳嗽、面红、鸡鸣样回声、呕吐症状(P均<0.05)。哮喘未合并百日咳者以晨起咳嗽多见(9.36% vs. 4.20%, P=0.047),而在夜间、晨起及夜间、日间、运动后等的咳嗽时相性特点在两组中差异无统计学意义(P均>0.05)。两组间白细胞计数、中性粒细胞计数、淋巴细胞计数、嗜酸性粒细胞计数及IgE水平差异均无统计学意义(P均>0.05)。结论哮喘儿童百日咳检出率高,尤其是哮喘急性发作与百日咳密切相关,临床症状对两者有一定的鉴别意义,实验室检查结果对两种疾病无鉴别意义。建议对咳嗽持续时间>2~4周的哮喘患儿常规筛查百日咳,以更好地鉴别或判断,指导治疗。

关键词: 儿童, 百日咳, 感染, 哮喘, 相关性

Abstract: Objective To assess the prevalence of pertussis infection in children with asthma across different stages and subtypes and to analyze the correlation between the two diseases via a multicenter prospective investigation. Methods Information was collected from children with asthma who had a cough ≥1 week through questionnaires, and pertussis toxin(PT)IgG antibodies levels and/or pertussis nucleic acid tests were performed to interpret the results. The distribution of pertussis antibody, infection and clinical characteristics of different groups were analyzed according to different age, asthma stage and pertussis infection. Results Among the 1,049 asthmatic children, the positive rate of PT-IgG was 26.22%, and the rate was significantly higher in ≥6 years old group compared with 3 months -< 3 years old group and 3 years -< 6 years old group(both P<0.001). The overall rate of pertussis infection in asthmatic children was 25.17%, with an increasing trend in infection rates corresponding to advancing age(P<0.001). The incidence rate of cough variant asthma combined with pertussis infection was significantly higher than classical asthma(28.00% vs. 22.59%, P=0.040). According to the clinical characteristics of 656 children, the incidence rate of pertussis infection was higher in patients with acute asthma attack than in chronic duration and clinical remission(26.15% vs. 10.46%, P<0.001; 26.15% vs. 8.00%, P=0.042). There was no significant difference between newly diagnosed and recurrent cases of asthma(P=0.189). Asthmatic children with pertussis were more likely to have spasmodic cough, facial redness, chickenlike echo and vomiting symptoms than those without pertussis(all P< 0.05). Morning cough was more common in asthmatic children without pertussis(9.36% vs. 4.20%, P=0.047). There was no significant difference in other cough phase characteristics at night, morning or night, day and after exercise between the two groups(all P>0.05). There were no significant differences in leukocyte count, neutrophil count, lymphocyte count, eosinophilic count, and IgE levels between the two groups(all P> 0.05). Conclusion The pertussis detection is prevalent in children with asthma, especially during acute asthma exacerbation. Clinical symptoms have certain significance to distinguish the two diseases, but laboratory examination results show no significance between the two diseases. It is recommended that routine screening for pertussis should be conducted for asthmatic children with cough for more than 2-4 weeks to better identify or judge and guide treatment.

Key words: Child, Pertussis, Infectious disease, Asthma, Correlation

中图分类号:

R725.6

闫金燕,杨春,李雷,吴福玲,焦永莉,张晓蔚,李晶,张瑞珍,王磊,马香. 山东省儿童百日咳感染与哮喘的相关性[J]. 山东大学学报 (医学版), 2024, 62(7): 33-41.

YAN Jinyan, YANG Chun, LI Lei, WU Fuling, JIAO Yongli, ZHANG Xiaowei, LI Jing, ZHANG Ruizhen, WANG Lei, MA Xiang. Correlation between asthma and pertussis infection in children of Shandong Province, China[J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 33-41.

参考文献

[1] 国家呼吸系统疾病临床医学研究中心, 中华医学会儿科学分会呼吸学组哮喘协作组, 中国医药教育协会儿科专业委员会, 等. 中国儿童哮喘行动计划临床应用专家共识[J]. 中华实用儿科临床杂志, 2021, 36(7): 484-490. China National Clinical Research Center for Respiratory Diseases, Cooprative Group of Asthma, the Subspecialty Group of Respiratory, the Society of Pediatrics, Chinese Medical Association, China Medicine Education Association Committee on Pediatrics, et al. Expert consensus on clinical application of China Childrens Asthma Action Plan[J]. Chinese Journal of Applied Clinical Pediatrics, 2021, 36(7): 484-490.
[2] 国家呼吸系统疾病临床医学研究中心, 中华医学会儿科学分会呼吸学组哮喘协作组, 中国医药教育协会儿科专业委员会, 等. 中国儿童哮喘行动计划“百问百答”[J]. 中华实用儿科临床杂志, 2021, 36(7): 491-513. China National Clinical Research Center for Respiratory Diseases, Cooprative Group of Asthma,the Subspecialty Group of Respiratory, the Society of Pediatrics, Chinese Medical Association, China Medicine Education Association Committee on Pediatrics, et al. One hundred key issues on Chinese Childrens Asthma Action Plan[J]. Chinese Journal of Applied Clinical Pediatrics, 2021, 36(7): 491-513.
[3] Decker MD, Edwards KM. Pertussis(whooping cough)[J]. J Infect Dis, 2021, 224(Supplement_4): S310-S320.
[4] 中华预防医学会.中华预防医学会疫苗与免疫分会.中国百日咳行动计划专家共识[J]. 中华流行病学杂志,2021,42(6): 955-965. Chinese Preventive Medicine Association, Vaccine and Immunology Branch of the Chinese Preventive Medicine Association. [Expert consensus on the China Pertussis Initiative[J]. Chinese Journal of Epidemiology, 2021, 42(6): 955-965.
[5] 郏继航, 郭琴, 万朝敏. 百日咳再现与疫苗策略研究进展[J]. 中华儿科杂志, 2020, 58(8): 686-689. JIA Jihang, GUO Qin, WAN Chaomin. Resurgence and vaccine strategies of pertussis[J]. Chinese Journal of Pediatrics, 2020, 58(8): 686-689.
[6] 谢甜, 钟礼立, 黄寒, 等. 225例支气管哮喘急性发作患儿呼吸道病原体检出及临床特征分析[J]. 中国当代儿科杂志, 2020, 22(11): 1198-1203. XIE Tian, ZHONG Lili, HUANG Han, et al. Detection of respiratory pathogens and clinical features in 225 children with acute exacerbation of bronchial asthma[J]. Chinese Journal of Contemporary Pediatrics, 2020, 22(11): 1198-1203.
[7] 孟庆红, 丁明杰, 史伟, 等. 肺炎或哮喘住院患儿百日咳感染状况的血清学调查[J]. 贵州医科大学学报, 2017, 42(11): 1292-1296. MENG Qinghong, DING Mingjie, SHI Wei, et al. Seroprevalence analysis of pertussis infection of hospitalized children with clinical diagnoses of pneumonia or asthma[J]. Journal of Guizhou Medical University, 2017, 42(11): 1292-1296.
[8] Bhavsar A, Aris E, Harrington L, et al. Burden of pertussis in individuals with a diagnosis of asthma: a retrospective database study in England[J]. J Asthma Allergy, 2022, 15: 35-51. doi:10.2147/JAA.S335960.
[9] 中华医学会儿科学分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童支气管哮喘诊断与防治指南(2016年版)[J]. 中华儿科杂志, 2016, 54(3): 167-181.
[10] 中华医学会儿科学分会感染学组, 《中华儿科杂志》编辑委员会. 中国儿童百日咳诊断及治疗建议[J]. 中华儿科杂志, 2017, 55(8): 568-572.
[11] Tanriover MD, Soyler C, Ascioglu S, et al. Low seroprevalence of diphtheria, tetanus and pertussis in ambulatory adult patients: the need for lifelong vaccination[J]. Eur J Intern Med, 2014, 25(6): 528-532.
[12] Rubin K, Glazer S. The pertussis hypothesis: Bordetella pertussis colonization in the etiology of asthma and diseases of allergic sensitization[J]. Med Hypotheses, 2018, 120: 101-115. doi:10.1016/j.mehy.2018.08.006.
[13] Burgess JA, Abramson MJ, Gurrin LC, et al. Childhood infections and the risk of asthma: a longitudinal study over 37 years[J]. Chest, 2012, 142(3): 647-654.
[14] Macina D, Evans KE. Pertussis in individuals with co-morbidities: a systematic review[J]. Infect Dis Ther, 2021, 10(3): 1141-1170.
[15] Macina D, Mathur S, Dvaretskaya M, et al. Estimating the pertussis burden in adolescents and adults in the United States between 2007 and 2019[J]. Hum VaccinImmunother, 2023, 19(1): 2208514. doi:10.1080/21645515.2023.2208514.
[16] Liu BC, McIntyre P, Kaldor JM, et al. Pertussis in older adults: prospective study of risk factors and morbidity[J]. Clin Infect Dis, 2012, 55(11): 1450-1456.
[17] Chen J, Shin JY, Kim H, et al. Incidence and healthcare burden of pertussis among older adults with and without pre-existing chronic obstructive pulmonary disease or asthma in South Korea[J]. COPD, 2023, 20(1): 126-134.
[18] 吴丹, 郑徽,李明爽, 等. 中国2018—2021年百日咳流行病学特征[J]. 中国疫苗和免疫, 2022, 28(6): 638-643. WU Dan, ZHENG Wei, LI Mingshuang, et al. Epidemiology of pertussis in China, 2018-2021[J]. Chinese Journal of Vaccines and Immunization, 2022, 28(6): 638-643.
[19] Rosas-Salazar C, Chirkova T, Gebretsadik T, et al. Respiratory syncytial virus infection during infancy and asthma during childhood in the USA(INSPIRE): a population-based, prospective birth cohort study[J]. Lancet, 2023, 401(10389): 1669-1680.
[20] Luo JY, Chen HA, Zhang QY, et al. Metabolism characteristics of Mycoplasma pneumoniae infection in asthmatic children[J]. Allergy Asthma Immunol Res, 2022, 14(6): 713-729.
[21] Liu D, Tan YR, Bajinka O, et al. Th17/IL-17 axis regulated by airway microbes get involved in the development of asthma[J]. Curr Allergy Asthma Rep, 2020, 20(4): 11. doi:10.1007/s11882-020-00903-x.
[22] Kapil P, Merkel TJ. Pertussis vaccines and protective immunity[J]. Curr Opin Immunol, 2019, 59: 72-78. doi:10.1016/j.coi.2019.03.006.
[23] Borkner L, Curham LM, Wilk MM, et al. IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils[J]. Mucosal Immunol, 2021, 14(5): 1183-1202.
[24] Hammad H, Lambrecht BN. The basic immunology of asthma[J]. Cell, 2021, 184(6): 1469-1485.
[25] Kessie DK, Lodes N, Oberwinkler H, et al. Activity of tracheal cytotoxin of Bordetella pertussis in a human tracheobronchial 3D tissue model[J]. Front Cell Infect Microbiol, 2020, 10: 614994. doi:10.3389/fcimb.2020.614994.
[26] Sundqwist M, Trollfors B, Taranger J. Pertussis in infancy does not increase the risk of asthma[J]. Pediatrics, 1998, 102(6): 1496-1497.
[27] 杨飏, 沈俊. 491例儿童慢性咳嗽病因及其临床特征分析[J]. 中华肺部疾病杂志(电子版), 2022, 15(4): 542-544. YANG Yang, SHEN Jun. Analysis of etiology and clinical features of 491 chronic cough children[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2022, 15(4): 542-544.
[28] 中华医学会儿科学分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童慢性咳嗽诊断与治疗指南(试行)[J]. 中华儿科杂志, 2008, 46(2): 104-107.
[29] Ding HM, Xu XH, Wen SW, et al. Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China[J]. J Thorac Dis, 2019, 11(8): 3482-3489.
[30] Lai KF, Chen RC, Lin JT, et al. A prospective, multicenter survey on causes of chronic cough in China[J]. Chest, 2013, 143(3): 613-620.
[31] 李翠彤, 黄玉芬, 向宇俊. 83例慢性咳嗽患儿百日咳感染情况临床分析[J]. 中国妇幼保健, 2022, 37(20): 3781-3784. LI Cuitong, HUANG Yufen, XIANG Yujun. Clinical analysis of pertussis infection in 83 children with chronic cough[J]. Maternal and Child Health Care of China, 2022, 37(20): 3781-3784.
[32] 吕曦, 李玮菡. 百日咳感染在儿童慢性咳嗽中的临床特征研究[J]. 中国实用医药, 2021, 16(1): 26-28. LYU Xi, LI Weihan. Study on the clinical characteristics of pertussis infection in children with chronic cough[J]. China Practical Medicine, 2021, 16(1): 26-28.
[33] 滕瑞红, 付丽, 柳俊芳, 等. 儿童咳嗽变异性哮喘误诊原因分析[J]. 临床误诊误治, 2020, 33(7): 1-4. TENG Ruihong, FU Li, LIU Junfang, et al. Analysis on misdiagnosis causes of children with cough variant asthma[J]. Clinical Misdiagnosis & Mistherapy, 2020, 33(7): 1-4.
[34] 王宗润, 米荣. 百日咳研究现状[J]. 当代医学, 2018, 24(6): 174-177. WANG Zongrun, MI Rong. Research status of whooping cough[J]. Contemporary Medicine, 2018, 24(6): 174-177.
[35] 中华医学会,中华医学会杂志社,中华医学会全科医学分会,等. 支气管哮喘基层诊疗指南(2018年)[J]. 中华全科医师杂志, 2018, 17(10): 751-762. Chinese Medical Association, Chinese Medical Journals Publishing House, Chinese Society of General Practice, et al. Guideline for primary care of bronchial asthma(2018)[J]. Chinese Journal of General Practitioners, 2018, 17(10): 751-762.
[36] 荆小袁, 陆敏. 上海地区儿童百日咳鲍特杆菌毒素IgG抗体的血清流行病学调查[J]. 中国感染与化疗杂志, 2018, 18(6): 585-591. JING Xiaoyuan, LU Min. The seroepidemiology of anti-Bordetella pertussis toxin IgG antibodies among children in Shanghai[J]. Chinese Journal of Infection and Chemotherapy, 2018, 18(6): 585-591.
[37] Novosad J, Krcmová I. Evolution of our view on the IgE molecule role in bronchial asthma and the clinical effect of its modulation by omalizumab: where do we stand today?[J]. Int J Immunopathol Pharmacol, 2020, 34: 2058738420942386. doi:10.1177/2058738420942386.
[38] 闫金燕,李小敏,马香.儿童哮喘与百日咳关系机制的研究进展[J].结核与肺部疾病杂志, 2023, 4(1): 78-84. YAN Jinyan, LI Xiaomin, MA Xiang. Research progress on the mechanism of the relationship between asthma and Pertussis[J]. Journal of Tuberculosis and Lung Disease, 2023, 4(1): 78-84.
[39] 梁磊, 成孟瑜, 段炜, 等. 口服糖皮质激素对哮喘患者全身及局部气道炎症反应的影响[J]. 中国医药, 2022, 17(11): 1634-1637. LIANG Lei, CHENG Mengyu, DUAN Wei, et al. Effects of oral glucocorticoids on systemic and local airway inflammation in patients with asthma[J]. China Medicine, 2022, 17(11): 1634-1637.
[40] 杜晓刚, 董新威, 陈季强, 等. 百日咳蛋白对小鼠过敏性哮喘模型的免疫调节作用[J]. 浙江大学学报(医学版), 2008, 37(4): 351-356. DU Xiaogang, DONG Xinwei, CHEN Jiqiang, et al. Immunoregulatory effects of pertussis protein on allergic asthma in mouse[J]. Journal of Zhejiang University(Medical Sciences), 2008, 37(4): 351-356.
[41] Belcher T, Ait-Yahia S, Solans L, et al. Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice[J]. NPJ Vaccines, 2022, 7(1): 66. doi:10.1038/s41541-022-00494-w.
[42] Nicolai A, Nenna R, Stefanelli P, et al. Bordetella pertussis in infants hospitalized for acute respiratory symptoms remains a concern[J]. BMC Infect Dis, 2013, 13: 526. doi:10.1186/1471-2334-13-526.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

山东省儿童百日咳感染与哮喘的相关性

Correlation between asthma and pertussis infection in children of Shandong Province, China

PDF (PC)

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

多维度评价

本文评价

推荐阅读 10

[1]	孙丛丛,崔文静,张锦涛,张东,刘晓菲,潘云,亓倩,徐嘉蔚,曾荣,郭红喜,董亮. 铁死亡在支气管哮喘气道重塑中的作用[J]. 山东大学学报 (医学版), 2024, 62(7): 1-9.
[2]	王静,刘晓菲,曾荣,许长娟,张锦涛,董亮. 基于机器学习算法鉴定哮喘的坏死性凋亡相关生物标志物[J]. 山东大学学报 (医学版), 2024, 62(7): 21-32.
[3]	张学宇,张学海,孙文青,刘晗,姜金波,刘寒,李远,陈晓梅. 重症新型冠状病毒肺炎伴侵袭性肺曲霉病及反复致命性消化道出血1例[J]. 山东大学学报 (医学版), 2024, 62(7): 56-61.
[4]	张锦涛,董亮. 气道上皮及其源性细胞因子与哮喘:思考与展望[J]. 山东大学学报 (医学版), 2024, 62(5): 1-6.
[5]	丁伊人,刘婉莹,姚蕾,姚欣. 大环内酯类抗生素治疗哮喘的研究进展[J]. 山东大学学报 (医学版), 2024, 62(5): 21-27.
[6]	王婷,张丽,王刚. 神经心理性哮喘[J]. 山东大学学报 (医学版), 2024, 62(5): 28-34.
[7]	徐芳,田国雄,孙倍倍,陈馨怡,陈高莹,张睿琦,应颂敏,吴妙莲,张超,吴优倩. 重度哮喘的生物与细胞疗法研究进展[J]. 山东大学学报 (医学版), 2024, 62(5): 35-42.
[8]	石硕川,曾荣,张锦涛,张东,潘云,刘晓菲,许长娟,王莹,董亮. 基于生物信息学探索支气管哮喘中的潜在差异免疫基因和免疫浸润特征[J]. 山东大学学报 (医学版), 2024, 62(5): 43-53.
[9]	王靖婷,王璟,鲁艺,李静坦,李强,郏雁飞,马晓丽. α5-nAChR与MHC-I在肺腺癌中的表达及相关性[J]. 山东大学学报 (医学版), 2024, 62(5): 72-78.
[10]	曹丹凤,李慧. 儿童期不良经历对妊娠期抑郁症状的影响:母胎依恋的中介作用[J]. 山东大学学报 (医学版), 2024, 62(3): 87-91.
[11]	宋甜田,李作坤,王书会. 个体化预测老年心脏瓣膜置换术后医院感染风险Nomogram模型的构建[J]. 山东大学学报 (医学版), 2024, 62(1): 48-56.
[12]	吕龙飞,李继如,翟允鹏,赵华善,郭锐,许洪修,黄赛,张士松. 单术者双孔法在电视辅助胸腔镜手术治疗儿童叶外型肺隔离症中的早期临床应用[J]. 山东大学学报 (医学版), 2024, 62(1): 57-62.
[13]	符晓莉,魏绪霞,徐俊杰,薛宁,张乐,陈红苓. 儿童自身免疫性肠病1例并文献复习[J]. 山东大学学报 (医学版), 2023, 61(9): 118-124.
[14]	王骏仁,李道卫,王星光,姜淑娟. 吸入布地奈德/福莫特罗治疗新型冠状病毒感染后咳嗽的疗效[J]. 山东大学学报 (医学版), 2023, 61(8): 50-53.
[15]	陈天杰,张晓华,王瑞霞,赵淑磊. 超声内镜引导下细针穿刺抽吸术诊断胰腺淋巴管瘤合并术后感染1例[J]. 山东大学学报 (医学版), 2023, 61(7): 121-124.